6V2G
Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp. Covalent acyl-enzyme intermediate and tetrahedral intermediate.
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PRK04183 | e6v2gA2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
A | Asparaginase | e6v2gA1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
C | PRK04183 | e6v2gC1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
C | Asparaginase | e6v2gC2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
D | PRK04183 | e6v2gD2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
D | Asparaginase | e6v2gD1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
B | PRK04183 | e6v2gB2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
B | Asparaginase | e6v2gB1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00710 | Asparaginase, N-terminal (Asparaginase) | Asparaginase, N-terminal | This is the N-terminal domain of this enzyme. | Domain | |
PF17763 | Glutaminase/Asparaginase C-terminal domain (Asparaginase_C) | Glutaminase/Asparaginase C-terminal domain | This domain is found at the C-terminus of asparaginase enzymes. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR027473 | L-asparaginase, C-terminal | Homologous Superfamily | |
IPR027475 | Asparaginase/glutaminase, active site 2 | Active Site | |
IPR036152 | Asparaginase/glutaminase-like superfamily | Homologous Superfamily | |
IPR020827 | Asparaginase/glutaminase, active site 1 | Active Site | |
IPR037152 | L-asparaginase, N-terminal domain superfamily | Homologous Superfamily | |
IPR040919 | Asparaginase/glutaminase, C-terminal | Domain | |
IPR027474 | L-asparaginase, N-terminal | Domain | |
IPR004550 | L-asparaginase, type II | Family | |
IPR006034 | Asparaginase/glutaminase-like | Family |