Degradation of human hemoglobin by organic C-nitroso compounds.
Yi, J., Ye, G., Thomas, L.M., Richter-Addo, G.B.(2013) Chem Commun (Camb) 49: 11179-11181
- PubMed: 24149619 
- DOI: https://doi.org/10.1039/c3cc46174b
- Primary Citation of Related Structures:  
4M4A, 4M4B - PubMed Abstract: 
The crystal structure of the nitrosomethane adduct of human Hb shows N-binding of the MeNO ligands to heme Fe. The structure of the EtNO adduct reveals a surprising 4.9 Å heme slippage in the β subunit, and explains the ability of C-nitroso compounds to degrade Hb removing it from circulation.
Organizational Affiliation: 
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA. [email protected] [email protected].