Annotations: 8YAL

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], D [auth E]	PF00091	Tubulin/FtsZ family, GTPase domain (Tubulin)	Tubulin/FtsZ family, GTPase domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ...	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	Domain
A [auth B], D [auth E]	PF03953	Tubulin C-terminal domain (Tubulin_C)	Tubulin C-terminal domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tub ...	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	Domain
B [auth C], F [auth I]	PF05301	GNAT acetyltransferase, Mec-17 (Acetyltransf_16)	GNAT acetyltransferase, Mec-17	-	Family
C [auth D], E [auth F]	PF00091	Tubulin/FtsZ family, GTPase domain (Tubulin)	Tubulin/FtsZ family, GTPase domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ...	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	Domain
C [auth D], E [auth F]	PF03953	Tubulin C-terminal domain (Tubulin_C)	Tubulin C-terminal domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tub ...	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], D [auth E]	Tubulin alpha-3 chain	hydrolase activity catalytic activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding hydrolase activity catalytic activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural constituent of cytoskeleton structural molecule activity cation binding metal ion binding	cellular process cell cycle mitotic cell cycle behavior multicellular organismal process thigmotaxis response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior detection of external stimulus system process nervous system process cellular process cell cycle mitotic cell cycle behavior multicellular organismal process thigmotaxis response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior detection of external stimulus system process nervous system process detection of mechanical stimulus involved in sensory perception of touch sensory perception of touch detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception regulation of biological process regulation of response to external stimulus regulation of mechanosensory behavior biological regulation positive regulation of biological process regulation of behavior positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of behavior regulation of response to stimulus positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of mechanosensory behavior cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization positive regulation of detection of mechanical stimulus involved in sensory perception of touch regulation of system process positive regulation of nervous system process regulation of detection of mechanical stimulus involved in sensory perception of touch regulation of nervous system process regulation of sensory perception	cellular anatomical structure intracellular anatomical structure cytoplasm somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton cellular anatomical structure intracellular anatomical structure cytoplasm somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
B [auth C], F [auth I]	Alpha-tubulin N-acetyltransferase 2	catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity peptide N-acetyltransferase activity tubulin N-acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	behavior multicellular organismal process thigmotaxis developmental process cellular developmental process cell development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development behavior multicellular organismal process thigmotaxis developmental process cellular developmental process cell development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development cellular process system development regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process microtubule cytoskeleton organization biological regulation regulation of microtubule-based process regulation of organelle organization cellular component organization organelle organization microtubule-based process cellular component organization or biogenesis regulation of microtubule cytoskeleton organization cytoskeleton organization	polymeric cytoskeletal fiber intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
C [auth D], E [auth F]	Tubulin beta-1 chain	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding structural constituent of cytoskeleton structural molecule activity cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle behavior multicellular organismal process response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular process cell cycle mitotic cell cycle behavior multicellular organismal process response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization detection of external stimulus system process nervous system process detection of mechanical stimulus involved in sensory perception of touch sensory perception of touch detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus detection of stimulus involved in sensory perception regulation of biological process regulation of response to external stimulus regulation of mechanosensory behavior biological regulation positive regulation of biological process regulation of behavior positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of behavior regulation of response to stimulus positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of mechanosensory behavior positive regulation of detection of mechanical stimulus involved in sensory perception of touch regulation of system process positive regulation of nervous system process regulation of detection of mechanical stimulus involved in sensory perception of touch regulation of nervous system process regulation of sensory perception	cellular anatomical structure intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle cellular anatomical structure intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], D [auth E]	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
A [auth B], D [auth E]	IPR017975	Tubulin, conserved site	Conserved Site
A [auth B], D [auth E]	IPR023123	Tubulin, C-terminal	Homologous Superfamily
A [auth B], D [auth E]	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
A [auth B], D [auth E]	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
A [auth B], D [auth E]	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
A [auth B], D [auth E]	IPR002452	Alpha tubulin	Family
A [auth B], D [auth E]	IPR000217	Tubulin	Family
A [auth B], D [auth E]	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
B [auth C], F [auth I]	IPR038746	Alpha-tubulin N-acetyltransferase	Family
B [auth C], F [auth I]	IPR007965	Gcn5-related N-acetyltransferase (GNAT) domain, ATAT-type	Domain
C [auth D], E [auth F]	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
C [auth D], E [auth F]	IPR017975	Tubulin, conserved site	Conserved Site
C [auth D], E [auth F]	IPR023123	Tubulin, C-terminal	Homologous Superfamily
C [auth D], E [auth F]	IPR002453	Beta tubulin	Family
C [auth D], E [auth F]	IPR013838	Beta tubulin, autoregulation binding site	Binding Site
C [auth D], E [auth F]	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
C [auth D], E [auth F]	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
C [auth D], E [auth F]	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
C [auth D], E [auth F]	IPR000217	Tubulin	Family
C [auth D], E [auth F]	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily