Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyIntegrin alpha N-terminal domain 8042728 3000314 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyIntegrin alpha N-terminal domain 8042728 3000314 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPlexin repeat-like 8042732 3000415 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyvWA-like 8055554 3000832 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyvWA-like 8055554 3000832 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPlexin repeat-like 8042732 3000415 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFG-GAP_1ste7ubrA1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: FG-GAP_1stECOD (1.6)
CFG-GAP_1ste7ubrC1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: FG-GAP_1stECOD (1.6)
BINBe7ubrB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: INBECOD (1.6)
BIntegrin_betae7ubrB2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: vWA-likeF: Integrin_betaECOD (1.6)
BPSI_integrine7ubrB4 A: few secondary structure elementsX: Trefoil/Plexin domain-like (From Topology)H: Trefoil/Plexin domain-like (From Topology)T: Trefoil/Plexin domain-likeF: PSI_integrinECOD (1.6)
BMgrB_likee7ubrB3 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: MgrB_likeECOD (1.6)
DINBe7ubrD2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: INBECOD (1.6)
DIntegrin_betae7ubrD3 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: vWA-likeF: Integrin_betaECOD (1.6)
DPSI_integrine7ubrD4 A: few secondary structure elementsX: Trefoil/Plexin domain-like (From Topology)H: Trefoil/Plexin domain-like (From Topology)T: Trefoil/Plexin domain-likeF: PSI_integrinECOD (1.6)
DKOG1226_1ste7ubrD1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: KOG1226_1stECOD (1.6)
FC1-set_4e7ubrF2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
FV-sete7ubrF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
H [auth L]C1-set_4e7ubrL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
H [auth L]V-sete7ubrL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
EV-set_8e7ubrE2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
EC1-set_1e7ubrE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
G [auth H]V-set_8e7ubrH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
G [auth H]C1-set_1e7ubrH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
F,
H [auth L]
Light ChainIGKV14 Kappaintegrin alpha-iibSAbDab (2024-12-06)
E,
G [auth H]
Heavy ChainIGHV14 -integrin alpha-iibSAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF01839FG-GAP repeat (FG-GAP)FG-GAP repeat- Repeat
B, D
PF18372Integrin beta epidermal growth factor like domain 1 (I-EGF_1)Integrin beta epidermal growth factor like domain 1This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2 [1]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 do ...This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2 [1]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end [14].
Domain
B, D
PF17205Integrin plexin domain (PSI_integrin)Integrin plexin domainThis short disulphide rich domain is found at the N-terminus of integrin beta chains.Domain
B, D
PF00362Integrin beta chain VWA domain (Integrin_beta)Integrin beta chain VWA domainIntegrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Integrin alpha-IIb
B, D
Isoform Beta-3C of Integrin beta-3
F,
H [auth L]
10E5 Fab light chain---
E,
G [auth H]
10E5 Fab heavy chain---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C
PharosP08514
B, D
PharosP05106