6V24
Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp. Covalent acyl-enzyme intermediate.
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Glutaminase/Asparaginase | 8033474 | 3001625 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | PRK04183 | e6v24B1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
B | Asparaginase | e6v24B2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
C | PRK04183 | e6v24C2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
C | Asparaginase | e6v24C1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
A | PRK04183 | e6v24A2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
A | Asparaginase | e6v24A1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
D | PRK04183 | e6v24D2 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase C-terminal domain (From Topology) | H: Glutaminase/Asparaginase C-terminal domain (From Topology) | T: Glutaminase/Asparaginase C-terminal domain | F: PRK04183 | ECOD (1.6) |
D | Asparaginase | e6v24D1 | A: a/b three-layered sandwiches | X: Glutaminase/Asparaginase N-terminal domain (From Topology) | H: Glutaminase/Asparaginase N-terminal domain (From Topology) | T: Glutaminase/Asparaginase N-terminal domain | F: Asparaginase | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00710 | Asparaginase, N-terminal (Asparaginase) | Asparaginase, N-terminal | This is the N-terminal domain of this enzyme. | Domain | |
PF17763 | Glutaminase/Asparaginase C-terminal domain (Asparaginase_C) | Glutaminase/Asparaginase C-terminal domain | This domain is found at the C-terminus of asparaginase enzymes. | Domain | |
PF00710 | Asparaginase, N-terminal (Asparaginase) | Asparaginase, N-terminal | This is the N-terminal domain of this enzyme. | Domain | |
PF17763 | Glutaminase/Asparaginase C-terminal domain (Asparaginase_C) | Glutaminase/Asparaginase C-terminal domain | This domain is found at the C-terminus of asparaginase enzymes. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
AEI | Parent Component: THR :  AA0525 :  O-(L-isoaspartyl)-L-threonine (active site intermediate) MOD:01671 , O-(L-isoaspartyl)-L-threonine (cross-link) MOD:01947 | |
AEI | Parent Component: THR :  AA0525 , AA0525 :  O-(L-isoaspartyl)-L-threonine (active site intermediate) MOD:01671 , O-(L-isoaspartyl)-L-threonine (cross-link) MOD:01947 , O-(L-isoaspartyl)-L-threonine (active site intermediate) MOD:01671 , O-(L-isoaspartyl)-L-threonine (cross-link) MOD:01947 |