Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
QSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
QSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
QSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
RSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
USCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
USCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
USCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
VSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)
VSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
VSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATPP_enzyme_Me6u9dA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
ATPP_enzyme_Ce6u9dA1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
ATPP_enzyme_Ne6u9dA3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
BTPP_enzyme_Me6u9dB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
BTPP_enzyme_Ce6u9dB3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
BTPP_enzyme_Ne6u9dB1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
ETPP_enzyme_Me6u9dE3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
ETPP_enzyme_Ce6u9dE2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
ETPP_enzyme_Ne6u9dE1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
FTPP_enzyme_Me6u9dF3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
FTPP_enzyme_Ce6u9dF1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
FTPP_enzyme_Ne6u9dF2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
ITPP_enzyme_Me6u9dI3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
ITPP_enzyme_Ce6u9dI1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
ITPP_enzyme_Ne6u9dI2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
JTPP_enzyme_Me6u9dJ1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
JTPP_enzyme_Ce6u9dJ3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
JTPP_enzyme_Ne6u9dJ2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
MTPP_enzyme_Me6u9dM2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
MTPP_enzyme_Ce6u9dM3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
MTPP_enzyme_Ne6u9dM1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
NTPP_enzyme_Me6u9dN2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
NTPP_enzyme_Ce6u9dN3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
NTPP_enzyme_Ne6u9dN1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
QTPP_enzyme_Me6u9dQ1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
QTPP_enzyme_Ce6u9dQ3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
QTPP_enzyme_Ne6u9dQ2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
RTPP_enzyme_Me6u9dR2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
RTPP_enzyme_Ce6u9dR3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
RTPP_enzyme_Ne6u9dR1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
UTPP_enzyme_Me6u9dU1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
UTPP_enzyme_Ce6u9dU3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
UTPP_enzyme_Ne6u9dU2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
VTPP_enzyme_Me6u9dV3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
VTPP_enzyme_Ce6u9dV2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
VTPP_enzyme_Ne6u9dV1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
A3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
B3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
B3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
E3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
E3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
F3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
F3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
J3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
J3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
M3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
M3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
N3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
N3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
U3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
U3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)
V3.40.50.970 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domainsCATH (utative)
V3.40.50.1220 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold TPP-binding domainCATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, E, F, I
PF00205Thiamine pyrophosphate enzyme, central domain (TPP_enzyme_M)Thiamine pyrophosphate enzyme, central domainThe central domain of TPP enzymes contains a 2-fold Rossman fold.Domain
A, B, E, F, I
PF02775Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (TPP_enzyme_C)Thiamine pyrophosphate enzyme, C-terminal TPP binding domain- Domain
A, B, E, F, I
PF02776Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (TPP_enzyme_N)Thiamine pyrophosphate enzyme, N-terminal TPP binding domain- Domain
C, D, G, H, K
PF01842ACT domain (ACT)ACT domainThis family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulati ...This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine [1]. Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585
Domain
C, D, G, H, K
PF10369Small subunit of acetolactate synthase (ALS_ss_C)Small subunit of acetolactate synthaseALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase. Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in bran ...ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase. Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in branched-chain amino acid biosynthesis. This reaction is sensitive to certain herbicides [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, E, F, I
Acetolactate synthase catalytic subunit, mitochondrial
C, D, G, H, K
Acetolactate synthase small subunit, mitochondrial

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, E, F, I
IPR045229Thiamine pyrophosphate enzymeFamily
A, B, E, F, I
IPR012001Thiamine pyrophosphate enzyme, N-terminal TPP-binding domainDomain
A, B, E, F, I
IPR000399TPP-binding enzyme, conserved siteConserved Site
A, B, E, F, I
IPR012000Thiamine pyrophosphate enzyme, central domainDomain
A, B, E, F, I
IPR012846Acetolactate synthase, large subunit, biosyntheticFamily
A, B, E, F, I
IPR029061Thiamin diphosphate-binding foldHomologous Superfamily
A, B, E, F, I
IPR039368Acetolactate synthase large subunit, TPP binding domainDomain
A, B, E, F, I
IPR029035DHS-like NAD/FAD-binding domain superfamilyHomologous Superfamily
A, B, E, F, I
IPR011766Thiamine pyrophosphate enzyme, TPP-bindingDomain
C, D, G, H, K
IPR004789Acetolactate synthase, small subunitFamily
C, D, G, H, K
IPR027271Acetolactate synthase/Transcription factor NikR, C-terminalHomologous Superfamily
C, D, G, H, K
IPR045865ACT-like domainHomologous Superfamily
C, D, G, H, K
IPR002912ACT domainDomain
C, D, G, H, K
IPR053050Acetolactate synthase regulatory subunitFamily
C, D, G, H, K
IPR039557AHAS, ACT domainDomain
C, D, G, H, K
IPR054480Acetolactate synthase small subunit-like, ACT domainDomain
C, D, G, H, K
IPR019455Acetolactate synthase, small subunit, C-terminalDomain