Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6q0da1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad6q0da2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6q0dd1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd6q0dd2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6q0de1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed6q0de2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6q0df1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Fd6q0df2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6q0db1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd6q0db2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6q0dc1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd6q0dc2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Lactate dehydrogenase Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyLDH/MDH/AglA-like 8057306 3000039 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALdh_1_C_13e6q0dA1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ALdh_1_Ne6q0dA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
DLdh_1_C_13e6q0dD1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
DLdh_1_Ne6q0dD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
ELdh_1_C_13e6q0dE2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ELdh_1_Ne6q0dE1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
FLdh_1_C_13e6q0dF1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
FLdh_1_Ne6q0dF2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
BLdh_1_C_13e6q0dB2 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
BLdh_1_Ne6q0dB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
CLdh_1_C_13e6q0dC1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
CLdh_1_Ne6q0dC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02866lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C)lactate/malate dehydrogenase, alpha/beta C-terminal domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Domain
A, B, C, D, E
PF00056lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N)lactate/malate dehydrogenase, NAD binding domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
L-lactate dehydrogenase A chain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR011304L-lactate dehydrogenaseFamily
A, B, C, D, E
IPR018177L-lactate dehydrogenase, active siteActive Site
A, B, C, D, E
IPR015955Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalHomologous Superfamily
A, B, C, D, E
IPR001557L-lactate/malate dehydrogenaseFamily
A, B, C, D, E
IPR001236Lactate/malate dehydrogenase, N-terminalDomain
A, B, C, D, E
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR022383Lactate/malate dehydrogenase, C-terminalDomain