6Q0D
CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00384414-01 AT 2.05 A RESOLUTION
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | LDH/MDH/AglA-like | 8057306 | 3000039 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Ldh_1_C_13 | e6q0dA1 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
A | Ldh_1_N | e6q0dA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
D | Ldh_1_C_13 | e6q0dD1 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
D | Ldh_1_N | e6q0dD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
E | Ldh_1_C_13 | e6q0dE2 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
E | Ldh_1_N | e6q0dE1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
F | Ldh_1_C_13 | e6q0dF1 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
F | Ldh_1_N | e6q0dF2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
B | Ldh_1_C_13 | e6q0dB2 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
B | Ldh_1_N | e6q0dB1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
C | Ldh_1_C_13 | e6q0dC1 | A: a+b complex topology | X: LDH C-terminal domain-like (From Topology) | H: LDH C-terminal domain-like (From Topology) | T: LDH C-terminal domain-like | F: Ldh_1_C_13 | ECOD (1.6) |
C | Ldh_1_N | e6q0dC2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Ldh_1_N | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02866 | lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C) | lactate/malate dehydrogenase, alpha/beta C-terminal domain | L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ... | Domain | |
PF00056 | lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N) | lactate/malate dehydrogenase, NAD binding domain | L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR011304 | L-lactate dehydrogenase | Family | |
IPR018177 | L-lactate dehydrogenase, active site | Active Site | |
IPR015955 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | Homologous Superfamily | |
IPR001557 | L-lactate/malate dehydrogenase | Family | |
IPR001236 | Lactate/malate dehydrogenase, N-terminal | Domain | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR022383 | Lactate/malate dehydrogenase, C-terminal | Domain |