6GIU

Human IMPase with L-690330

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6giub_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	Inositol monophosphatase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6giua_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	Inositol monophosphatase	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Carbohydrate phosphatase-like	8037476	3001721	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Carbohydrate phosphatase-like	8037476	3001721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Inositol_P_N	e6giuB1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
B	Inositol_P_C	e6giuB2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)
A	Inositol_P_N	e6giuA1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
A	Inositol_P_C	e6giuA2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
B	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)
A	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
A	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00459	Inositol monophosphatase family (Inositol_P)	Inositol monophosphatase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Inositol monophosphatase 1	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity lithium ion binding alkali metal ion binding identical protein binding protein binding protein homodimerization activity protein dimerization activity inositol monophosphate 1-phosphatase activity manganese ion binding transition metal ion binding inositol monophosphate 3-phosphatase activity	polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process small molecule biosynthetic process inositol biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process phosphatidylinositol metabolic process polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process small molecule biosynthetic process inositol biosynthetic process biosynthetic process organic hydroxy compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR033942	Inositol monophosphatase	Family
A, B	IPR020552	Inositol monophosphatase, lithium-sensitive	Family
A, B	IPR020550	Inositol monophosphatase, conserved site	Conserved Site
A, B	IPR020583	Inositol monophosphatase, metal-binding site	Binding Site
A, B	IPR000760	Inositol monophosphatase-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P29218	intellectual disability, autosomal recessive 59 bipolar disorder visual epilepsy Jacksonian Seizure osteoarthritis rheumatoid arthritis X-linked mixed deafness with perilymphatic gusher intellectual disability juvenile idiopathic arthritis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm hereditary spastic paraplegia ovarian carcinoma plasma cell myeloma IgA glomerulonephritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.