6FS7

Influenza A/California/04/2009 (pH1N1) endonuclease with I38T mutation with bound inhibitor, baloxavir acid (BXA)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6fs7b1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
B	d6fs7b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
F	d6fs7f1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
F	d6fs7f2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
A	d6fs7a1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
A	d6fs7a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
C	d6fs7c1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
C	d6fs7c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
D	d6fs7d1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
D	d6fs7d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
E	d6fs7e1	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	PA N-terminal domain	PA N-terminal domain	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)
E	d6fs7e2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ], (Influenza A virus (A/California/04/2009(H1N1)) ) [TaxId: 641501 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Flu_PA_N	e6fs7B1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)
F	Flu_PA_N	e6fs7F1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)
A	Flu_PA_N	e6fs7A1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)
C	Flu_PA_N	e6fs7C1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)
D	Flu_PA_N	e6fs7D1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)
E	Flu_PA_N	e6fs7E1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: Flu_PA_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)
F	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)
A	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)
C	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)
D	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)
E	3.40.91.90	Alpha Beta	3-Layer(aba) Sandwich	Restriction Endonuclease	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Polymerase acidic protein,Polymerase acidic protein	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	symbiont-mediated suppression of host transcription biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity symbiont-mediated perturbation of host process modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process symbiont-mediated suppression of host transcription biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity symbiont-mediated perturbation of host process modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process cellular process macromolecule metabolic process viral gene expression cap snatching negative stranded viral RNA transcription viral transcription RNA-templated viral transcription viral translational frameshifting viral translation gene expression DNA-templated transcription	host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle host cell cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001009	Influenza RNA-dependent RNA polymerase subunit PA	Family
A, B, C, D, E A, B, C, D, E, F	IPR037534	Polymerase acidic protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR038372	Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.