4D11

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ricin_B_lectin	e4d11A2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
A	Glycos_transf_2	e4d11A3	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
B	Ricin_B_lectin	e4d11B2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
B	Glycos_transf_2	e4d11B1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
D	Ricin_B_lectin	e4d11D2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
D	Glycos_transf_2	e4d11D3	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
E	Ricin_B_lectin	e4d11E2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
E	Glycos_transf_2	e4d11E3	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
F	Glycos_transf_2	e4d11F1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)
C	Ricin_B_lectin	e4d11C2	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: Ricin_B_lectin	ECOD (1.6)
C	Glycos_transf_2	e4d11C1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: Glycos_transf_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
B	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
B	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
D	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
D	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
E	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
E	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
F	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)
C	3.90.550.10	Alpha Beta	Alpha-Beta Complex	Spore Coat Polysaccharide Biosynthesis Protein SpsA	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, D, E, F	PF00535	Glycosyl transferase family 2 (Glycos_transf_2)	Glycosyl transferase family 2	-	Family
A, B, D, E, F	PF00652	Ricin-type beta-trefoil lectin domain (Ricin_B_lectin)	Ricin-type beta-trefoil lectin domain	-	Domain
C	PF00535	Glycosyl transferase family 2 (Glycos_transf_2)	Glycosyl transferase family 2	-	Family
C	PF00652	Ricin-type beta-trefoil lectin domain (Ricin_B_lectin)	Ricin-type beta-trefoil lectin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	PEPTIDE	extracellular matrix binding binding protein binding growth factor binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation labyrinthine layer blood vessel development placenta blood vessel development placenta development chordate embryonic development animal organ development labyrinthine layer development embryo development developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation labyrinthine layer blood vessel development placenta blood vessel development placenta development chordate embryonic development animal organ development labyrinthine layer development embryo development in utero embryonic development vasculature development circulatory system development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching anatomical structure development embryonic organ development blood vessel development system development heart development ventricular septum development cardiac septum development cardiac chamber development cardiac ventricle development cardiac atrium morphogenesis cardiac chamber morphogenesis heart morphogenesis cardiac atrium development anatomical structure morphogenesis cardiac septum morphogenesis atrial septum morphogenesis animal organ morphogenesis atrial septum development reactive oxygen species metabolic process metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion positive regulation of cellular process cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization positive regulation of programmed cell death positive regulation of apoptotic process connective tissue development tissue development chondroblast differentiation skeletal system development cartilage development apoptotic process involved in heart morphogenesis apoptotic process involved in morphogenesis apoptotic process involved in development regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cellular response to stimulus response to stimulus signaling signal transduction cell communication embryonic morphogenesis chorio-allantoic fusion embryonic placenta morphogenesis labyrinthine layer morphogenesis cell-cell adhesion blood vessel morphogenesis tube development angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis intussusceptive angiogenesis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion regulation of cartilage development regulation of multicellular organismal development positive regulation of multicellular organismal process positive regulation of cartilage development regulation of multicellular organismal process atrioventricular valve development heart valve development heart valve morphogenesis atrioventricular valve morphogenesis regulation of amide metabolic process sphingolipid biosynthetic process regulation of lipid metabolic process positive regulation of ceramide biosynthetic process lipid biosynthetic process positive regulation of sphingolipid biosynthetic process regulation of primary metabolic process cellular component biogenesis positive regulation of metabolic process regulation of sphingolipid biosynthetic process positive regulation of biosynthetic process positive regulation of lipid metabolic process amide metabolic process regulation of ceramide biosynthetic process ceramide metabolic process membrane lipid metabolic process regulation of biosynthetic process regulation of membrane lipid metabolic process amide biosynthetic process sphingolipid metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of cellular component biogenesis macromolecule biosynthetic process biosynthetic process positive regulation of lipid biosynthetic process ceramide biosynthetic process positive regulation of amide metabolic process regulation of macromolecule biosynthetic process membrane lipid biosynthetic process regulation of lipid biosynthetic process macromolecule metabolic process regulation of metabolic process lipid metabolic process	cell periphery extracellular matrix cellular anatomical structure external encapsulating structure extracellular region
A, B, D, E, F	POLYPEPTIDE GALNAC-TRANSFERASE T2	binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity hexosyltransferase activity catalytic activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process peptidyl-threonine modification protein O-linked glycosylation via threonine protein modification process gene expression protein maturation peptidyl-serine modification protein O-linked glycosylation via serine O-glycan processing	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm membrane extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm membrane extracellular region Golgi membrane bounding membrane of organelle organelle membrane Golgi cisterna membrane Golgi cisterna perinuclear region of cytoplasm endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
C	POLYPEPTIDE GALNAC-TRANSFERASE T2	binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity binding carbohydrate binding cation binding manganese ion binding transition metal ion binding ion binding metal ion binding small molecule binding UDP-glycosyltransferase activity polypeptide N-acetylgalactosaminyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity transferase activity acetylgalactosaminyltransferase activity hexosyltransferase activity catalytic activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation peptidyl-amino acid modification metabolic process cellular process protein metabolic process macromolecule metabolic process peptidyl-threonine modification protein O-linked glycosylation via threonine protein modification process gene expression protein maturation peptidyl-serine modification protein O-linked glycosylation via serine O-glycan processing	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm membrane extracellular region membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure organelle Golgi stack cytoplasm membrane extracellular region Golgi membrane bounding membrane of organelle organelle membrane Golgi cisterna membrane Golgi cisterna perinuclear region of cytoplasm endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR012395	IGFBP-related, CNN	Family
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR001007	VWFC domain	Domain
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR000867	Insulin-like growth factor-binding protein, IGFBP	Domain
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR043973	CCN, TSP1 domain	Domain
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR050941	Cellular Communication Network Factor	Family
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR006208	Glycoprotein hormone subunit beta	Domain
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR006207	Cystine knot, C-terminal	Domain
G [auth L], H [auth O], I [auth P], J [auth X], K [auth Z]	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site	Conserved Site
A, B, D, E, F	IPR045885	N-acetylgalactosaminyltransferase	Domain
A, B, D, E, F	IPR035992	Ricin B-like lectins	Homologous Superfamily
A, B, D, E, F	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B, D, E, F	IPR001173	Glycosyltransferase 2-like	Domain
A, B, D, E, F	IPR000772	Ricin B, lectin domain	Domain
C	IPR045885	N-acetylgalactosaminyltransferase	Domain
C	IPR035992	Ricin B-like lectins	Homologous Superfamily
C	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
C	IPR001173	Glycosyltransferase 2-like	Domain
C	IPR000772	Ricin B, lectin domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, D, E, F	Pharos: Q10471	metabolic syndrome X pancreatic ductal adenocarcinoma pilocytic astrocytoma astrocytic tumor breast carcinoma diabetes mellitus lung adenocarcinoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma atypical teratoid rhabdoid tumor congenital disorder of glycosylation gastric carcinoma lung cancer metabolic syndrome X pancreatic ductal adenocarcinoma pilocytic astrocytoma astrocytic tumor breast carcinoma diabetes mellitus lung adenocarcinoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma atypical teratoid rhabdoid tumor congenital disorder of glycosylation gastric carcinoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis breast cancer Crohn disease glioblastoma lymphoplasmacytic lymphoma malignant mesothelioma oligodendroglioma
C	Pharos: Q10471	metabolic syndrome X pancreatic ductal adenocarcinoma pilocytic astrocytoma astrocytic tumor breast carcinoma diabetes mellitus lung adenocarcinoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma atypical teratoid rhabdoid tumor congenital disorder of glycosylation gastric carcinoma lung cancer metabolic syndrome X pancreatic ductal adenocarcinoma pilocytic astrocytoma astrocytic tumor breast carcinoma diabetes mellitus lung adenocarcinoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm plasma cell myeloma atypical teratoid rhabdoid tumor congenital disorder of glycosylation gastric carcinoma lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis breast cancer Crohn disease glioblastoma lymphoplasmacytic lymphoma malignant mesothelioma oligodendroglioma