Annotations: 3W7T

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PRK10137	e3w7tB1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: PRK10137	ECOD (1.6)
B	Glyco_hydro_63	e3w7tB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_63	ECOD (1.6)
A	PRK10137	e3w7tA1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: PRK10137	ECOD (1.6)
A	Glyco_hydro_63	e3w7tA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Glyco_hydro_63	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.70.98.50	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
B	1.10.287.100	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
B	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
B	3.30.1390.40	Alpha Beta	2-Layer Sandwich	Ribosomal Protein L30	Chain: A,	CATH (4.3.0)
A	2.70.98.50	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
A	1.10.287.100	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
A	3.30.1390.40	Alpha Beta	2-Layer Sandwich	Ribosomal Protein L30	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF22422	Mannosylglycerate hydrolase MGH1-like glycoside hydrolase domain (MGH1-like_GH)	Mannosylglycerate hydrolase MGH1-like glycoside hydrolase domain	This entry represents the glycoside hydrolase domain found at the C-terminal of Mannosylglycerate hydrolase MGH1 and similar sequences.	Domain
A, B	PF21152	Glucosidase YgjK, N-terminal (YgjK_N)	Glucosidase YgjK, N-terminal	This domain is found at the N-terminal end of Glucosidase YgjK from Escherichia coli and similar bacterial enzymes from the glycoside hydrolase family 63 (GH63) from bacteria, archaea, and eukaryotes. YgjK is organised into N- and A- domains and a li ...	This domain is found at the N-terminal end of Glucosidase YgjK from Escherichia coli and similar bacterial enzymes from the glycoside hydrolase family 63 (GH63) from bacteria, archaea, and eukaryotes. YgjK is organised into N- and A- domains and a linker between them. This entry includes the N-domain and the linker. The N-domain is composed of 18 antiparallel beta-strands divided into two beta- sheets and is classified as a super-beta-sandwich. The linker is composed of two helices and produces a significant curvature between the two domains [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Uncharacterized protein YgjK	hydrolase activity, acting on glycosyl bonds alpha,alpha-trehalase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity trehalase activity catalytic activity glucosidase activity cation binding ion binding binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process disaccharide metabolic process metabolic process disaccharide catabolic process	protein-containing complex catalytic complex glucosidase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
A, B	IPR048450	Glucosidase YgjK, N-terminal domain	Domain
A, B	IPR001661	Glycoside hydrolase, family 37	Family
A, B	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.