3KXX

Structure of the mutant Fibroblast Growth Factor receptor 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036668	3000066	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036668	3000066	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036668	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036668	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e3kxxA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e3kxxB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D	Pkinase_Tyr	e3kxxD2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C	Pkinase_Tyr	e3kxxC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Basic fibroblast growth factor receptor 1	protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity signaling receptor binding receptor-receptor interaction fibroblast growth factor binding growth factor binding SH2 domain binding protein domain specific binding molecular transducer activity fibroblast growth factor receptor activity signaling receptor activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity heparin binding glycosaminoglycan binding sulfur compound binding	regulation of localization localization regulation of biological process regulation of transport transport biological regulation phosphate ion transport regulation of phosphate transport establishment of localization inorganic anion transport response to fibroblast growth factor cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus regulation of localization localization regulation of biological process regulation of transport transport biological regulation phosphate ion transport regulation of phosphate transport establishment of localization inorganic anion transport response to fibroblast growth factor cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus response to growth factor cellular response to fibroblast growth factor stimulus regulation of phospholipase activity positive regulation of phospholipase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of lipase activity regulation of molecular function positive regulation of molecular function positive regulation of hydrolase activity regulation of hydrolase activity regulation of lipase activity developmental process ear morphogenesis embryonic organ morphogenesis multicellular organismal process ear development sensory organ development embryonic morphogenesis animal organ development embryo development multicellular organism development anatomical structure morphogenesis outer ear morphogenesis sensory organ morphogenesis anatomical structure development animal organ morphogenesis embryonic organ development regulation of neuron projection development regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization cellular response to stimulus signaling intracellular signal transduction cell communication phosphatidylinositol-mediated signaling signal transduction regulation of postsynaptic specialization assembly cellular component biogenesis cellular component assembly cell junction assembly regulation of excitatory synapse assembly postsynaptic density organization regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of postsynaptic density organization postsynapse organization organelle assembly postsynaptic specialization assembly postsynapse assembly regulation of postsynapse organization regulation of cellular component biogenesis regulation of organelle organization excitatory synapse assembly regulation of cell junction assembly regulation of synapse organization organelle organization cell junction organization regulation of organelle assembly postsynaptic specialization organization synapse assembly postsynaptic density assembly regulation of postsynaptic density assembly inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of vascular endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation vascular endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of vascular endothelial cell proliferation protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process signal transduction in absence of ligand regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand regulation of signaling cell surface receptor signaling pathway regulation of apoptotic process cell death regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus skeletal system development skeletal system morphogenesis mitotic DNA replication positive regulation of mitotic cell cycle DNA replication positive regulation of DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of mitotic cell cycle positive regulation of nuclear cell cycle DNA replication positive regulation of cell cycle process positive regulation of macromolecule metabolic process positive regulation of mitotic cell cycle cell cycle regulation of nucleobase-containing compound metabolic process regulation of cell cycle cell cycle process DNA-templated DNA replication positive regulation of nucleobase-containing compound metabolic process regulation of nuclear cell cycle DNA replication regulation of mitotic cell cycle DNA replication regulation of cell cycle process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of cell cycle DNA replication mitotic cell cycle process positive regulation of DNA metabolic process regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process connective tissue development tissue development chondrocyte differentiation cartilage development negative regulation of biological process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process regulation of developmental process specification of animal organ identity pattern specification process developmental induction positive regulation of developmental process animal organ formation regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of animal organ morphogenesis regionalization positive regulation of animal organ morphogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process regulation of animal organ formation organ induction middle ear morphogenesis inner ear development inner ear morphogenesis positive regulation of cell communication regulation of parathyroid hormone secretion regulation of hormone secretion regulation of system process positive regulation of secretion by cell hormone secretion positive regulation of parathyroid hormone secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion positive regulation of secretion signal release secretion regulation of hormone levels export from cell cell-cell signaling parathyroid hormone secretion regulation of secretion endocrine process endocrine hormone secretion positive regulation of transport hormone transport regulation of endocrine process positive regulation of signaling neuroblast proliferation forebrain development forebrain neuroblast division ventricular zone neuroblast division cell proliferation in forebrain head development forebrain generation of neurons neuroblast division brain development central nervous system development forebrain ventricular zone progenitor cell division cell division neural precursor cell proliferation positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation anatomical structure maturation cell maturation developmental maturation cell projection assembly embryo development ending in birth or egg hatching chordate embryonic development positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of signal transduction positive regulation of phosphorylation regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process intracellular signaling cassette positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of phosphorus metabolic process positive regulation of MAPK cascade regulation of protein metabolic process positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of response to stimulus positive regulation of protein modification process regulation of intracellular signal transduction positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity MAPK cascade regulation of phosphorylation mesenchymal-epithelial cell signaling gland development branching involved in salivary gland morphogenesis gland morphogenesis salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of morphogenesis of an epithelium regulation of morphogenesis of a branching structure epithelium development morphogenesis of an epithelium salivary gland development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling tissue morphogenesis morphogenesis of a branching structure exocrine system development morphogenesis of a branching epithelium cementum mineralization tooth mineralization odontogenesis biomineral tissue development regulation of fibroblast growth factor production cytokine production regulation of cytokine production fibroblast growth factor production negative regulation of cytokine production negative regulation of fibroblast growth factor production negative regulation of gene expression negative regulation of multicellular organismal process heart development heart growth developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth striated muscle tissue development circulatory system development muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation regulation of growth regulation of cardiac muscle tissue growth positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation positive regulation of developmental growth positive regulation of heart growth regulation of multicellular organismal development regulation of developmental growth positive regulation of organ growth positive regulation of growth positive regulation of cardiac muscle tissue growth inner ear receptor cell development epidermis development epithelial cell differentiation hair cell differentiation mechanoreceptor differentiation epidermal cell differentiation inner ear auditory receptor cell differentiation inner ear receptor cell differentiation auditory receptor cell development regulation of cell differentiation positive regulation of cell differentiation regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation in utero embryonic development protein autophosphorylation paraxial mesoderm development mesenchyme development mesoderm development mesenchymal cell differentiation epithelial to mesenchymal transition mesodermal cell differentiation lateral mesodermal cell fate specification mesoderm morphogenesis lateral mesoderm development lateral mesoderm morphogenesis regulation of mesodermal cell fate specification regulation of lateral mesodermal cell fate specification regulation of mesodermal cell differentiation mesodermal cell fate commitment lateral mesoderm formation mesoderm formation mesodermal cell fate specification formation of primary germ layer mesenchyme morphogenesis regulation of cell fate commitment cell fate specification lateral mesodermal cell differentiation gastrulation cell fate commitment involved in formation of primary germ layer regulation of cell fate specification lateral mesodermal cell fate commitment cell fate commitment response to sodium phosphate response to chemical response to salt diphosphate metabolic process oxoacid metabolic process small molecule metabolic process organic acid metabolic process midbrain development blood vessel morphogenesis tube development angiogenesis vasculature development tube morphogenesis blood vessel development lung-associated mesenchyme development respiratory tube development lung development respiratory system development regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway peptidyl-tyrosine modification peptidyl-amino acid modification peptidyl-tyrosine phosphorylation ureteric bud development mesonephric epithelium development kidney epithelium development mesonephros development renal system development kidney development mesonephric tubule development regulation of response to external stimulus positive regulation of chemotaxis positive regulation of response to external stimulus taxis positive regulation of endothelial cell chemotaxis endothelial cell chemotaxis cell chemotaxis chemotaxis regulation of endothelial cell chemotaxis response to external stimulus regulation of chemotaxis cellular response to chemical stimulus positive regulation of neuron differentiation regulation of neuron differentiation fat-soluble vitamin metabolic process organic hydroxy compound metabolic process steroid metabolic process alcohol metabolic process vitamin D3 metabolic process vitamin D metabolic process vitamin metabolic process secondary alcohol metabolic process lipid metabolic process orbitofrontal cortex development limbic system development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development neuron migration stem cell differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle intracellular vesicle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle intracellular vesicle intracellular membrane-bounded organelle vesicle extracellular region synapse cell junction glutamatergic synapse postsynapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B, C, D	IPR000719	Protein kinase domain	Domain
A, B, C, D	IPR003599	Immunoglobulin domain subtype	Domain
A, B, C, D	IPR028174	Fibroblast growth factor receptor 1, catalytic domain	Domain
A, B, C, D	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B, C, D	IPR016248	Fibroblast growth factor receptor family	Family
A, B, C, D	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B, C, D	IPR003598	Immunoglobulin subtype 2	Domain
A, B, C, D	IPR013098	Immunoglobulin I-set	Domain
A, B, C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR050122	Receptor Tyrosine Kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P11362	Kallmann syndrome osteoglophonic dwarfism Pfeiffer syndrome cleft palate astrocytic tumor craniosynostosis Jackson-Weiss syndrome encephalocraniocutaneous lipomatosis pilocytic astrocytoma squamous cell carcinoma Hartsfield-Bixler-Demyer syndrome giant cell glioblastoma gliosarcoma hypogonadotropic hypogonadism 2 with or without anosmia non-small cell lung carcinoma Kallmann syndrome osteoglophonic dwarfism Pfeiffer syndrome cleft palate astrocytic tumor craniosynostosis Jackson-Weiss syndrome encephalocraniocutaneous lipomatosis pilocytic astrocytoma squamous cell carcinoma Hartsfield-Bixler-Demyer syndrome giant cell glioblastoma gliosarcoma hypogonadotropic hypogonadism 2 with or without anosmia non-small cell lung carcinoma malignant glioma breast carcinoma holoprosencephaly melancholia childhood cerebral astrocytoma schizophrenia intellectual disability Craniofacial Abnormalities anaplastic astrocytoma gemistocytic astrocytoma cancer mixed glioma trigonocephaly 1 fibrillary astrocytoma bone marrow neoplasm breast cancer protoplasmic astrocytoma cleft lip septooptic dysplasia small cell lung carcinoma subependymal giant cell astrocytoma juvenile pilocytic astrocytoma endogenous depression Klinefelter syndrome hypogonadotropic hypogonadism small cell carcinoma myeloid neoplasm associated with FGFR1 rearrangement interstitial lung disease depressive disorder isolated trigonocephaly acrocephalosyndactyly oligodendroglioma ductal breast carcinoma in situ thyroid gland follicular carcinoma trigonocephaly endometrial carcinoma lobar holoprosencephaly pancreatic ductal adenocarcinoma lung disease atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia glioma major depressive disorder bipolar disorder breast adenocarcinoma polydactyly head and neck neoplasm hydrocephalus hypogonadotropic hypogonadism 1 with or without anosmia cholangiocarcinoma semilobar holoprosencephaly idiopathic pulmonary fibrosis squamous cell lung carcinoma neurotic disorder thyroid gland papillary carcinoma Antley-Bixler syndrome osteosarcoma lung benign neoplasm astrocytoma (excluding glioblastoma) pancreatic intraductal papillary-mucinous carcinoma lung large cell carcinoma autism spectrum disorder malignant ependymoma Pick disease head and neck cancer heart valve disease cerebral astrocytoma myeloproliferative neoplasm invasive ductal breast carcinoma diffuse astrocytoma thymic carcinoma tooth agenesis adrenal cortex carcinoma osteogenesis imperfecta tuberculosis Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis ovarian cancer gastric carcinoma lung cancer attention deficit hyperactivity disorder, inattentive type pancreatic intraductal papillary-mucinous neoplasm glioblastoma biliary tract cancer Pfeiffer syndrome type 1 head and neck carcinoma renal cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.