2VC2
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2vc2a_ | All beta proteins | 7-bladed beta-propeller | Integrin alpha N-terminal domain | Integrin alpha N-terminal domain | Integrin alpha N-terminal domain | HUMAN (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C [auth H] | d2vc2h_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | automated matches | (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
D [auth L] | d2vc2l2 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | C1 set domains (antibody constant domain-like) | automated matches | (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
D [auth L] | d2vc2l1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | (Mus musculus ) [TaxId: 10090 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Integrin alpha N-terminal domain | 8042728 | 3000314 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Integrin domains | 8055552 | 3002062 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Plexin repeat-like | 8042732 | 3000415 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | vWA-like | 8055554 | 3000832 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Integrin domains | 8055552 | 3002062 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | FG-GAP_1st | e2vc2A1 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: FG-GAP_1st | ECOD (1.6) |
B | INB | e2vc2B3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: INB | ECOD (1.6) |
B | Integrin_beta | e2vc2B2 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: vWA-like | F: Integrin_beta | ECOD (1.6) |
B | PSI_integrin | e2vc2B1 | A: few secondary structure elements | X: Trefoil/Plexin domain-like (From Topology) | H: Trefoil/Plexin domain-like (From Topology) | T: Trefoil/Plexin domain-like | F: PSI_integrin | ECOD (1.6) |
C [auth H] | V-set_8 | e2vc2H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
C [auth H] | C1-set_1 | e2vc2H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
D [auth L] | C1-set_4 | e2vc2L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
D [auth L] | V-set | e2vc2L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.130.10.130 | Mainly Beta | 7 Propeller | Methylamine Dehydrogenase | Chain H | CATH (4.3.0) |
B | 3.30.1680.10 | Alpha Beta | 2-Layer Sandwich | ligand-binding face of the semaphorins, domain 2 | ligand-binding face of the semaphorins, domain 2 | CATH (4.3.0) |
B | 2.60.40.1510 | Mainly Beta | Sandwich | Immunoglobulin-like | ntegrin, alpha v. Chain A, domain 3 | CATH (4.3.0) |
B | 3.40.50.410 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | von Willebrand factor, type A domain | CATH (4.3.0) |
C [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
D [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
INTEGRIN-ALPHA-IIB_BETA-3 | INTEGRIN-ALPHA-IIB | Homo sapiens (human) | ALPHA-IIB | A-LIKE-DOMAIN B-Propeller | RPI | INTEGRIN-ALPHA-IIB_BETA-3 | IMGT (202448-0) | |
INTEGRIN-ALPHA-IIB_BETA-3 | INTEGRIN-BETA-3 | Homo sapiens (human) | BETA-3 | P-LIKE-DOMAIN PSI, Y-LIKE-DOMAIN Hybrid-1, B-LIKE-DOMAIN BETA-1, Y-LIKE-DOMAIN Hybrid-2, E-LIKE-DOMAIN EGF-1 | RPI | INTEGRIN-ALPHA-IIB_BETA-3 | IMGT (202448-0) | |
C [auth H] | 10E5 | VH-CH1 | Mus musculus (house mouse) | IGHV14-3*02, IGHJ4*01, IGHG2A*01, IGHG2A*02 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-2A_KAPPA | IMGT (202448-0) |
D [auth L] | 10E5 | L-KAPPA | Mus musculus (house mouse) | IGKV14-100*01, IGKJ2*01, IGKC*01, IGKC*02 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-2A_KAPPA | IMGT (202448-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
C [auth H] | Heavy Chain | IGHV14 | - | integrin alpha-iib | SAbDab (2024-12-06) |
D [auth L] | Light Chain | IGKV14 | Kappa | integrin alpha-iib | SAbDab (2024-12-06) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01839 | FG-GAP repeat (FG-GAP) | FG-GAP repeat | - | Repeat | |
PF18372 | Integrin beta epidermal growth factor like domain 1 (I-EGF_1) | Integrin beta epidermal growth factor like domain 1 | This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2 [1]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 do ... | Domain | |
PF17205 | Integrin plexin domain (PSI_integrin) | Integrin plexin domain | This short disulphide rich domain is found at the N-terminus of integrin beta chains. | Domain | |
PF00362 | Integrin beta chain VWA domain (Integrin_beta) | Integrin beta chain VWA domain | Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain. | Domain | |