Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
B [auth H]d1bj1h1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
B [auth H]d1bj1h2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
F [auth K]d1bj1k1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
F [auth K]d1bj1k2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
A [auth L]d1bj1l1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
A [auth L]d1bj1l2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth J]d1bj1j1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
E [auth J]d1bj1j2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa house mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
C [auth V]d1bj1v_ Small proteins Cystine-knot cytokines Cystine-knot cytokines Platelet-derived growth factor-like Vascular endothelial growth factor, VEGF Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth W]d1bj1w_ Small proteins Cystine-knot cytokines Cystine-knot cytokines Platelet-derived growth factor-like Vascular endothelial growth factor, VEGF Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
B [auth H]V-set_8e1bj1H1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
B [auth H]C1-set_1e1bj1H2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
F [auth K]V-set_8e1bj1K1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
F [auth K]C1-set_1e1bj1K2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
A [auth L]C1-set_4e1bj1L2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
A [auth L]V-sete1bj1L1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
E [auth J]C1-set_4e1bj1J2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
E [auth J]V-sete1bj1J1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
C [auth V]PDGFe1bj1V1 A: few secondary structure elementsX: Cystine-knot cytokines (From Topology)H: Cystine-knot cytokines (From Topology)T: Cystine-knot cytokinesF: PDGFECOD (1.6)
D [auth W]PDGFe1bj1W1 A: few secondary structure elementsX: Cystine-knot cytokines (From Topology)H: Cystine-knot cytokines (From Topology)T: Cystine-knot cytokinesF: PDGFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
B [auth H],
F [auth K]
12-IgG1 Fab, F(ab)-12 IgG1, Fab-12 IgG1, rhuMAb-VEGF Fab VH-CH1 Humanized (humanized) IGHV3-23*03, IGHV3-30*02, IGHV3-NL1*01, IGHV3-30-5*02, IGHJ2*01, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202446-0)
A [auth L],
E [auth J]
12-IgG1 Fab, F(ab)-12 IgG1, Fab-12 IgG1, rhuMAb-VEGF Fab L-KAPPA Humanized (humanized) IGKV1-16*01, IGKV1-39*01, IGKV1D-39*01, IGKJ1*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202446-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
B [auth H],
F [auth K]
Heavy ChainIGHV7 -vascular endothelial growth factorSAbDab (2024-11-15)
A [auth L],
E [auth J]
Light ChainIGKV1 Kappavascular endothelial growth factorSAbDab (2024-11-15)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
B [auth H],
F [auth K]
Ivonescimab VEGFA, PDCD1/CD279/PD1, ANGPT2Therapeutic SAbDab (2024-11-15)
A [auth L],
E [auth J]
Ranibizumab VEGFA, PDCD1/CD279/PD1, ANGPT2Therapeutic SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth V],
D [auth W]
PF00341PDGF/VEGF domain (PDGF)PDGF/VEGF domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
B [auth H],
F [auth K]
Fab fragment, heavy chain---
A [auth L],
E [auth J]
Fab fragment, light chain---
C [auth V],
D [auth W]
Vascular endothelial growth factor A

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth V],
D [auth W]
PharosP15692