Download MendeleyNuclear GTPSCS functions as a lactyl-CoA ligase to promote histone lactylation and glioma progression
Liu, R.L., Ren, X.L., Feng, H.X., Sheng, X.L., Li, L.T., Zhang, Y., Huang, H., Zhao, Y.M.To be published.
8Z02
CoA bound to human GTP-specific succinyl-CoA synthetase
- PDB DOI: https://doi.org/10.2210/pdb8Z02/pdb
- Classification: LIGASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2024-04-08 Released: 2024-12-11
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), National Institutes of Health/National Cancer Institute (NIH/NCI), National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.32 Å
- R-Value Free: 0.249
- R-Value Work: 0.212
- R-Value Observed: 0.214
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 321 | Homo sapiens | Mutation(s): 0 Gene Names: SUCLG1 EC: 6.2.1.4 (PDB Primary Data), 6.2.1.5 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P53597 (Homo sapiens) Explore P53597 Go to UniProtKB: P53597 | |||||
PHAROS: P53597 GTEx: ENSG00000163541 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P53597 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial | 395 | Homo sapiens | Mutation(s): 0 Gene Names: SUCLG2 EC: 6.2.1.4 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q96I99 (Homo sapiens) Explore Q96I99 Go to UniProtKB: Q96I99 | |||||
PHAROS: Q96I99 GTEx: ENSG00000172340 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q96I99 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| COA (Subject of Investigation/LOI) Query on COA | C [auth A] | COENZYME A C21 H36 N7 O16 P3 S RGJOEKWQDUBAIZ-IBOSZNHHSA-N |  | ||
| PO4 (Subject of Investigation/LOI) Query on PO4 | D [auth A] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.32 Å
- R-Value Free: 0.249
- R-Value Work: 0.212
- R-Value Observed: 0.214
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 56.63 | α = 90 |
| b = 105.7 | β = 90 |
| c = 126.77 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| XDS | data reduction |
| Aimless | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-12-11 Deposition Author(s): Liu, R.L., Ren, X.L., Li, L.T., Zhang, Y., Huang, H., Zhao, Y.M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | GM135504 |
| National Institutes of Health/National Cancer Institute (NIH/NCI) | United States | CA251677 |
| National Natural Science Foundation of China (NSFC) | China | 81973164 |
Revision History (Full details and data files)
- Version 1.0: 2024-12-11
Type: Initial release
