Y3G

5-ethynylpyrimidine-2,4(1H,3H)-dione


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Chemical Component Summary

Name5-ethynylpyrimidine-2,4(1H,3H)-dione
Identifiers5-ethynyl-1~{H}-pyrimidine-2,4-dione
FormulaC6 H4 N2 O2
Molecular Weight136.108
TypeNON-POLYMER
Isomeric SMILESC#CC1=CNC(=O)NC1=O
InChIInChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
InChIKeyJOZGNYDSEBIJDH-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count14
Chiral Atom Count0
Bond Count14
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB03516 
NameEniluracil
Groups investigational
DescriptionEniluracil, which was previously under development by GlaxoSmithKline (GSK), is being developed by Adherex to enhance the therapeutic value and effectiveness of 5-fluorouracil (5-FU), one of the world’s most widely-used oncology agents. 5-FU is widely used in the U.S. and is often first or second line therapy for a variety of cancers including colorectal, breast, gastric, head and neck, ovarian and basal cell cancer of the skin. Eniluracil could improve 5-FU by increasing its effectiveness, reducing its side effects and/or making it orally available. Eniluracil has received Orphan Drug status from the FDA for the treatment of hepatocellular cancer in combination with fluoropyrimidines (including 5-FU).
Synonyms
  • 5-Ethynyluracil
  • Eniluracil
IndicationFor the treatment of cancer in combination with 5-fluorouracil.
Categories
  • Enzyme Inhibitors
  • Pyrimidines
  • Pyrimidinones
CAS number59989-18-3

Drug Targets

NameTarget SequencePharmacological ActionActions
Aldehyde oxidaseMDRASELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCG...unknown
Xanthine dehydrogenase/oxidaseMTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGA...unknowninhibitor
Dihydropyrimidine dehydrogenase [NADP(+)]MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCF...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL355200
PubChem 43157, 5273947
ChEMBL CHEMBL355200