UN9

N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE

Find entries where: UN9

is present as a standalone ligand in 18 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

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Chemical Component Summary
Name	N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Identifiers	2-[(1-chloro-4-hydroxy-isoquinolin-3-yl)carbonylamino]ethanoic acid
Formula	C₁₂ H₉ Cl N₂ O₄
Molecular Weight	280.664
Type	NON-POLYMER
Isomeric SMILES	c1ccc2c(c1)c(c(nc2Cl)C(=O)NCC(=O)O)O
InChI	InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
InChIKey	OUQVKRKGTAUJQA-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	28
Chiral Atom Count	0
Bond Count	29
Aromatic Bond Count	11

Drug Info: DrugBank

DrugBank ID	DB08687
Name	FG-2216
Groups	investigational
Description	A orally active prolyl-hydroxylase inhibitor which can stabilize hypoxia-inducible transcription factor independent of oxygen availability. [A14422]
Synonyms	(((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid 1-Chloro-N-(hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide FG-2216
Indication	Investigated for use/treatment in anemia and kidney disease.
CAS number	223387-75-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Egl nine homolog 1	MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQD...	unknown
Hypoxia-inducible factor 1-alpha	MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNV...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682