Nitroglycerin, also known as glyceryl trinitrate,[A180169] is an organic nitrate and a vasodilating agent [L38369] that was first discovered in 1847.[A249965] Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain.[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins.[A180172] Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart failure,[L7099] and chronic anal fissure.[L42445] It is also used to induce intraoperative hypotension.[L7099]
Synonyms
Propane-1,2,3-triyl trinitrate
Nitroglycerin
Trinitrine
Trinitroglycerin
Glycerin trinitrate
Glycerol, nitric acid triester
Glyceryl trinitrate
1,2,3-propanetriyl nitrate
1,2,3-propanetrioltrinitrate
Trinitroglycerol
NG
Nitroglycerol
Glyceroli trinitratis
Glycerol trinitrate
Nitromed
Nitroglycerine
Nitroglicerina
Glyceroltrinitrat
Brand Names
Nitro-dur 0.2
Nitroglycerin Transdermal Delivery System
Nitroglycerin Transdermal System
Rectiv
Nitrostat
Nitrolingual Pumpspray
Nitrong SR Srt 2.6mg
Apo-nitroglycerin
Transderm-nitro 0.2
Trinipatch 0.6
Nitroglycerin
Nitroglycerin In 5% Dextrose Inj.-200mcg/ml
Nitrol
Transderm-nitro 0.4
Nitroglycerin Transdermal Infusion System
Gonitro
Nitro-Time
Nitroglycerin ER
Nitroglycerin In 5% Dextrose Inj.-400mcg/ml
Nitroglycerin Injection USP
NitroMist
Nitroglycerin In Dextrose
Trinipatch 0.2
Nitroglycerin Slocaps
Nitro-dur 0.3 - 60mg/15 Sq Cm, 0.3mg/hr
Nitro-dur 0.4
Nitro-dur 0.6
Mylan-nitro Patch 0.6
Nitro-dur
Mylan-nitro Patch 0.8
Nitroglycerin in Dextrose
Mylan-nitro Sublingual Spray
Basic Dental Emergency Kit
Deluxe Dental Emergency Kit
Nitronal
Rho-nitro Pumpspray
Nitro-time
Nitroglycerin SR
Nitrolingual
Minitran - Patch Trd 72mg/26.6 Sq Cm
Nitroglycerin Inj 5mg/ml
Transderm-nitro 0.6
Transderm-nitro 0.8
Nitro-dur 0.8
Minitran
Mylan-nitro Patch 0.4
Nitro-bid
Mylan-nitro Patch 0.2
Nitroject
Nitroglycerin Lingual
Nitroglycerin In 5% Dextrose Inj.-100mcg/ml
Trinipatch 0.4
Transderm Nitro
Nitroject Inj 1mg/ml
Nitrogard-SR Tab 1mg
Tridil Injection 5mg/ml
Nitrolingual Spray 0.4mg/eam
Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.[L7102,L38369,L42320] Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.[L7141] Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.[L7099] Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.[L42445]
Categories
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Antianginal Agents
Antihypertensive Agents
Cardiac Therapy
Cardiovascular Agents
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
