THG

(6S)-5,6,7,8-TETRAHYDROFOLATE

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is present as a standalone ligand in 33 entries

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Chemical Component Summary
Name	(6S)-5,6,7,8-TETRAHYDROFOLATE
Identifiers	(2S)-2-[[4-[[(6S)-2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl]methylamino]phenyl]carbonylamino]pentanedioic acid
Formula	C₁₉ H₂₃ N₇ O₆
Molecular Weight	445.429
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC[C@H]2CNC3=C(N2)C(=O)NC(=N3)N
InChI	InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11-,12-/m0/s1
InChIKey	MSTNYGQPCMXVAQ-RYUDHWBXSA-N

Chemical Details
Formal Charge	0
Atom Count	55
Chiral Atom Count	2
Bond Count	57
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB02031
Name	(6S)-5,6,7,8-tetrahydrofolic acid
Groups	experimental
Synonyms	(6S)-5,6,7,8-tetrahydrofolate (6S)-Tetrahydrofolic acid (6S)-5,6,7,8-tetrahydropteroylglutamate (6S)-THFA (6S)-H4folate (6S)-tetrahydrofolate (6S)-5,6,7,8-tetrahydrofolic acid
Categories	Folic Acid and Derivatives Vitamin B Complex Vitamins
CAS number	135-16-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Nitric oxide synthase oxygenase	MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKE...	unknown
Thymidylate synthase	MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682