PRO

PROLINE

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is present as a standalone ligand in 162 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 33 entries

is present in a polymer sequence 219,255 entries

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Chemical Component Summary
Name	PROLINE
Identifiers	(2S)-pyrrolidine-2-carboxylic acid
Formula	C₅ H₉ N O₂
Molecular Weight	115.13
Type	L-PEPTIDE LINKING
Isomeric SMILES	C1C[C@H](NC1)C(=O)O
InChI	InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKey	ONIBWKKTOPOVIA-BYPYZUCNSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	1
Bond Count	17
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00172
Name	Proline
Groups	nutraceutical
Description	Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. Proline is sometimes called an imino acid, although the IUPAC definition of an imine requires a carbon-nitrogen double bond. Proline is a non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons.
Synonyms	(−)-(S)-proline (S)-pyrrolidine-2-carboxylic acid L-(−)-proline Prolina L-α-pyrrolidinecarboxylic acid (−)-proline Prolinum P 2-Pyrrolidinecarboxylic acid L-Proline (-)-2-Pyrrolidinecarboxylic acid (S)-2-Carboxypyrrolidine L-pyrrolidine-2-carboxylic acid L-Prolin L-Prolina L-alpha-pyrrolidinecarboxylic acid (S)-2-Pyrrolidinecarboxylic acid (2S)-pyrrolidine-2-carboxylic acid (−)-2-pyrrolidinecarboxylic acid Proline
Brand Names	4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Premasol - sulfite-free (Amino Acid) Aminosyn-PF 10% FreAmine III Travasol E Renamin (amino Acids) Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose ProcalAmine 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Aminosyn Sulfite Free Travasol 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 3.3% E Clinisol Primene 10%-liq IV 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II with Electrolytes Smofkabiven Vamin N Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. Periolimel 2.5% E 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex Plenamine Aminosyn 5% RenAmin 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix Primene 10% Novamine Aminosyn II 7% M In 10% Dextrose(dual Chamber) Perikabiven Olimel 5.7% E 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Essepna 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Aminosyn 10% W Electrolytes Aminosyn Aminosyn II 5% Inj Olimel 4.4% Aminosyn II Aminosyn II in Dextrose HepatAmine Aminosyn II 7% With 10% Dextrose 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec Travasol Amino Acid Inj 8.5% 8.5% Freamine III 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Peripheral Aminosyn 7% Travasol Amino Acid Inj 5.5% 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn II 8.5% Injection Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec Olimel 4.4% E Olimel 5.7% 2.75% Travas. Amino Acid InJ.W.elecw.25%dex Synthamin Aminosyn 8.5% Vamin 18 Electrolyte-free Smofkabiven Extra Nitrogen 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Nutrineal Pd4 Aminosyn II with Electrolytes in Dextrose with Calcium Aminosyn II In Dextrose Injection Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Primene Smofkabiven Electrolyte Free Aminosyn HF 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Travasol Inj Without Electrolytes 8.5% Kabiven 20% Prosol Hepatasol Travasol Inj Without Electrolytes 5.5% Aminosyn-PF Aminosyn II and Dextrose Aminosyn 3.5% M ProSol Aminosyn II 7% Injection Clinimix FreAmine HBC Aminosyn 8.5% Injection With Electrolytes Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Aminosyn-PF 7% Clinimix E TrophAmine Olimel 7.6% Olimel 7.6% E 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose 4.25%travasol Amino Acid InJ.W.elecw.5%dex.
Indication	L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Peptides, and Proteins Dietary Supplements Imino Acids Proteinogenic Amino Acids Supplements
CAS number	147-85-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Pyrroline-5-carboxylate reductase 1, mitochondrial	MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGV...	unknown
Bifunctional glutamate/proline--tRNA ligase	MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTD...	unknown
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMI...	unknown
Sodium-dependent proline transporter	MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSC...	unknown
Pyrroline-5-carboxylate reductase 2	MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGV...	unknown
Prolyl 4-hydroxylase subunit alpha-2	MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILV...	unknown
Proline dehydrogenase 1, mitochondrial	MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPV...	unknown
Peptidyl-prolyl cis-trans isomerase H	MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGE...	unknown
Proline synthase co-transcribed bacterial homolog protein	MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKP...	unknown
Prolyl 4-hydroxylase subunit alpha-1	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEE...	unknown
Peptidyl-prolyl cis-trans isomerase B	MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDL...	unknown	binder
Peptidyl-prolyl cis-trans isomerase F, mitochondrial	MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYL...	unknown
Peptidyl-prolyl cis-trans isomerase C	MGPGPRLLLPLVLCVGLGALVFSSGAEGFRKRGPSVTAKVFFDVRIGDKD...	unknown
Peptidyl-prolyl cis-trans isomerase A	MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKG...	unknown	binder
Peptidyl-prolyl cis-trans isomerase G	MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGT...	unknown
Prolyl 3-hydroxylase 1	MAVRALKLLTTLLAVVAAASQAEVESEAGWGMVTPDLLFAEGTAAYARGD...	unknown
Pyrroline-5-carboxylate reductase	MSVGFIGAGQLAMLWRGASRPQIPVGSQDNSQLPRNEPAHGVRAQEDGCE...	unknown
Probable proline--tRNA ligase, mitochondrial	MEGLLTRCRALPALATCSRQLSGYVPCRFHHCAPRRGRRLLLSRVFQPQN...	unknown
Prolyl 3-hydroxylase 2	MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYAS...	unknown
Prolyl 3-hydroxylase 3	MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAA...	unknown
Pyrroline-5-carboxylate reductase 3	MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCH...	unknown
Trans-L-3-hydroxyproline dehydratase	MESALAVPRLPPHDPGTPVLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAK...	unknown
Proline dehydrogenase 1, mitochondrial	MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPV...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682