PPF

PHOSPHONOFORMIC ACID

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is present as a standalone ligand in 10 entries

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Chemical Component Summary
Name	PHOSPHONOFORMIC ACID
Identifiers	phosphonomethanoic acid
Formula	C H₃ O₅ P
Molecular Weight	126.005
Type	NON-POLYMER
Isomeric SMILES	C(=O)(O)P(=O)(O)O
InChI	InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
InChIKey	ZJAOAACCNHFJAH-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	10
Chiral Atom Count	0
Bond Count	9
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00529
Name	Foscarnet
Groups	approved
Description	An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV.
Synonyms	Phosphonomethanoic acid Foscarmet Foscarnet sodium Foscarnet Phosphonoformic acid Carboxyphosphonic acid Phosphonoformate
Brand Names	Vocarvi Foscavir Foscarnet Sodium Foscarnet Foscavir UK
Indication	For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
Categories	Acetates Acids, Acyclic Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Chelating Activity Direct Acting Antivirals Enzyme Inhibitors Nephrotoxic agents Nucleic Acid Synthesis Inhibitors OAT1/SLC22A6 inhibitors Organophosphonates Organophosphorus Compounds Phosphonic Acid Derivatives Potential QTc-Prolonging Agents Pyrophosphate Analog DNA Polymerase Inhibitor QTc Prolonging Agents Reverse Transcriptase Inhibitors
ATC-Code	J05AD01
CAS number	4428-95-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA polymerase catalytic subunit	MFSGGGGPLSPGGKSAARAASGFFAPAGPRGASRGPPPCLRQNFYNPYLA...	unknown	inhibitor
DNA polymerase catalytic subunit	MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVM...	unknown	inhibitor
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
Monocarboxylate transporter 1	MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGI...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682