MAH

3-HYDROXY-3-METHYL-GLUTARIC ACID

Created:	2000-01-12
Last modified:	2024-09-27

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2 entries where MAH is found as a standalone ligand1 entries where MAH is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	21
Chiral Atom Count	0
Bond Count	20
Aromatic Bond Count	0

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Chemical Component Summary
Name	3-HYDROXY-3-METHYL-GLUTARIC ACID
Systematic Name (OpenEye OEToolkits)	3-hydroxy-3-methyl-pentanedioic acid
Formula	C₆ H₁₀ O₅
Molecular Weight	162.141
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)CC(O)(C)CC(=O)O
SMILES	CACTVS	3.341	CC(O)(CC(O)=O)CC(O)=O
SMILES	OpenEye OEToolkits	1.5.0	CC(CC(=O)O)(CC(=O)O)O
Canonical SMILES	CACTVS	3.341	CC(O)(CC(O)=O)CC(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(CC(=O)O)(CC(=O)O)O
InChI	InChI	1.03	InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)
InChIKey	InChI	1.03	NPOAOTPXWNWTSH-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB04377
Name	Meglutol
Groups	experimental
Description	An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Synonyms	Meglutol Dicrotalic acid 3-hydroxy-3-methylglutaric acid
Categories	Acids, Acyclic Anticholesteremic Agents Antimetabolites Dicarboxylic Acids Enzyme Inhibitors Glutarates Hypolipidemic Agents Lipid Modifying Agents Lipid Modifying Agents, Plain Lipid Regulating Agents
ATC-Code	C10AX05
CAS number	503-49-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
3-hydroxy-3-methylglutaryl-coenzyme A reductase	MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682