DTR

D-TRYPTOPHAN

Created:	1999-07-08
Last modified:	2023-11-03

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7 entries where DTR is found as a standalone ligand1 entries where DTR is covalently linked to polymer or other heterogen groups 110 entries where DTR is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	27
Chiral Atom Count	1
Bond Count	28
Aromatic Bond Count	10

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Chemical Component Summary
Name	D-TRYPTOPHAN
Systematic Name (OpenEye OEToolkits)	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
Formula	C₁₁ H₁₂ N₂ O₂
Molecular Weight	204.225
Type	D-PEPTIDE LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(N)Cc2c1ccccc1nc2
SMILES	CACTVS	3.341	N[CH](Cc1c[nH]c2ccccc12)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	c1ccc2c(c1)c(c[nH]2)CC(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc2c(c1)c(c[nH]2)C[C@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m1/s1
InChIKey	InChI	1.03	QIVBCDIJIAJPQS-SECBINFHSA-N

Drug Info: DrugBank

DrugBank ID	DB03225
Name	D-Tryptophan
Groups	experimental
Description	Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. The D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing structural characteristic of tryptophan is that it contains an indole functional group. It is an essential amino acid as defined by its growth effects on rats.
Synonyms	D-Tryptophan DTR (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan
CAS number	153-94-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
D-amino-acid oxidase	MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAG...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	6923517, 9060
ChEMBL	CHEMBL292303
ChEBI	CHEBI:57719, CHEBI:16296
CCDC/CSD	TAJSUV, QQQBTP02, RODSOU, IMENAR, TAKKAU, TRYPTB, TRYPTF10, XAMCEW, BEBCAP, TPTPCM, TRYPTC, QQQBTP05
COD	4517355