CPT

Cisplatin

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is present as a standalone ligand in 69 entries

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Chemical Component Summary
Name	Cisplatin
Synonyms	diammine(dichloro)platinum
Identifiers	bis(chloranyl)-bis($l^{4}-azanyl)platinum
Formula	Cl₂ H₆ N₂ Pt
Molecular Weight	300.045
Type	NON-POLYMER
Isomeric SMILES	[NH3][Pt]([NH3])(Cl)Cl
InChI	InChI=1S/2ClH.2H3N.Pt/h21H;21H3;/q;;;;+2/p-2
InChIKey	LXZZYRPGZAFOLE-UHFFFAOYSA-L

Chemical Details
Formal Charge	0
Atom Count	11
Chiral Atom Count	0
Bond Count	10
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00515
Name	Cisplatin
Groups	approved
Description	Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Synonyms	PLATINUM, DIAMMINEDICHLORO-, (SP-4-2)- Cis-DDP cis-diamminedichloroplatinum(II) CIS-DIAMMINEDICHLOROPLATINUM II Cisplatin CIS-DIAMMINEDICHLOROPLATINUM cisplatino (SP-4-2)-DIAMMINEDICHLOROPLATINUM INT230-6 COMPONENT CISPLATIN INT-230-6 COMPONENT CISPLATIN CDDP
Brand Names	Platinol-AQ Platinol Cisplatin Injection BP Platinol AQ Inj 1mg/ml CISplatin Cisplatin Injection Cisplatin Cisplatin Injection, BP PMS-cisplatin Cisplatin Injection, Mylan Std. Cisplatin Inj 0.5mg/ml Cisplatin Inj 1mg/ml
Indication	For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Categories	Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Cardiotoxic antineoplastic agents Chlorine Compounds Cholinesterase Inhibitors Compounds used in a research, industrial, or household setting Cross-Linking Reagents Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Drugs that are Mainly Renally Excreted Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index Immunosuppressive Agents Indicators and Reagents Laboratory Chemicals Myelosuppressive Agents Narrow Therapeutic Index Drugs Nephrotoxic agents Nitrogen Compounds OCT2 Inhibitors OCT2 Substrates OCT2 Substrates with a Narrow Therapeutic Index Platinum Compounds Radiation-Sensitizing Agents
ATC-Code	L01XA01
CAS number	15663-27-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA	-	unknown	cross-linking/alkylation
DNA-3-methyladenine glycosylase	MVTPALQMKKPKQFCRRMGQKKQRPARAGQPHSSSDAAQAPAEQPHSSSD...	unknown
Alpha-2-macroglobulin	MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVL...	unknown
Serotransferrin	MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIP...	unknown
Copper transport protein ATOX1	MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDT...	unknown
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	inducer
Xanthine dehydrogenase/oxidase	MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGA...	unknown	inducer
Cytochrome P450 4A11	MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQ...	unknown	inducer
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Arylamine N-acetyltransferase	MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLLGVPVD...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	inhibitor
Glutathione S-transferase theta-1	MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNP...	unknown	substrate
Metallothionein-1A	MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCIC...	unknown	substrate
Metallothionein-2	MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCIC...	unknown	substrate
Superoxide dismutase [Cu-Zn]	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHE...	unknown	substrate
Glutathione S-transferase P	MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLY...	unknown	substrate
NAD(P)H dehydrogenase [quinone] 1	MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPI...	unknown	substrate
Glutathione S-transferase Mu 1	MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEK...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown
Canalicular multispecific organic anion transporter 2	MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALP...	unknown	inducer
Multidrug resistance-associated protein 5	MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDAL...	unknown	inducer
Canalicular multispecific organic anion transporter 1	MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLH...	unknown	inducer
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
High affinity copper uptake protein 1	MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFG...	unknown	substrate
Probable low affinity copper uptake protein 2	MAMHFIFSDTAVLLFDFWSVHSPAGMALSVLVLLLLAVLYEGIKVGKAKL...	unknown	substrate
Multidrug resistance-associated protein 6	MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPI...	unknown	substrate
Copper-transporting ATPase 2	MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDG...	unknown	substrate
Copper-transporting ATPase 1	MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATI...	unknown	substrate
ATP-binding cassette sub-family G member 2	MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKS...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682