Chemical Component Summary

Name2-HYDROXY-4-AMINOBENZOIC ACID
Identifiers4-amino-2-hydroxy-benzoic acid
FormulaC7 H7 N O3
Molecular Weight153.135
TypeNON-POLYMER
Isomeric SMILESc1cc(c(cc1N)O)C(=O)O
InChIInChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChIKeyWUBBRNOQWQTFEX-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count18
Chiral Atom Count0
Bond Count18
Aromatic Bond Count6

Drug Info: DrugBank

DrugBank IDDB00233 
NameAminosalicylic acid
Groups approved
DescriptionAn antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.
Synonyms
  • Sodium aminosalicylate dihydrate
  • Aminosalicylate sodium anhydrous
  • 4-aminosalicylic acid
  • PAS
  • p-aminosalicylic acid
Brand Names
  • Paser
  • Nemasol Sodium Tab 500mg
  • Granupas
IndicationFor the treatment of tuberculosis
Categories
  • Acids, Carbocyclic
  • Aminobenzoates
  • Aminosalicylic Acid and Derivatives
  • Aminosalicylic Acids
  • Anti-Bacterial Agents
ATC-Code
  • J04AA02
  • J04AA03
  • J04AA01
CAS number65-49-6

Drug Targets

NameTarget SequencePharmacological ActionActions
Prostaglandin G/H synthase 2MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...unknowninhibitor
Inhibitor of nuclear factor kappa-B kinase subunit alphaMERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLEL...unknowninhibitor
Arachidonate 5-lipoxygenaseMPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...unknowninhibitor
Group IIE secretory phospholipase A2MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGG...unknownunknown
MyeloperoxidaseMGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...unknowninhibitor
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL1169
PubChem 4649
ChEMBL CHEMBL1169
ChEBI CHEBI:27565
CCDC/CSD URUDER, PAHHAK, URUDER01, PEXNAJ, FAYYAI, URUDER10, OFUYIZ, FAYXUB, URUDER02, FAYXOV, URUDER03, URUDER04, MOYZUX, XICRAE, URUDER06, URUDER05, CUKVEK, URUDER08, AMSALA01, URUDER07, YUJLOG01, LACWEU, AMSALA02, YUJLOG, BEYZAI, URUDER09, MABMUA, LACTAN, VUGMOZ, VATXOF, ICEBOK, COLKUL, OBOVAF, LACTUH, LACSUG, URUGIY, LACTER, LACWIY, LACTOB, VATXOF02, ZEQCEG, PEXPIT, LACTIV, AVEJOD
COD 1554036, 7206126, 7053091, 7206127, 7206128, 7206129, 4507570, 7206131, 7206130, 7206133, 7206132, 7208257, 7206134, 7206136