AZG

5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL

Created:	2003-11-10
Last modified:	2021-03-01

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7 entries where AZG is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	15
Chiral Atom Count	0
Bond Count	16
Aromatic Bond Count	10

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Chemical Component Summary
Name	5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL
Synonyms	8-AZAGUANINE
Systematic Name (OpenEye OEToolkits)	5-amino-1H-[1,2,3]triazolo[5,4-e]pyrimidin-7-ol
Formula	C₄ H₄ N₆ O
Molecular Weight	152.114
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c(O)c2c(nc1N)nnn2
SMILES	CACTVS	3.341	Nc1nc(O)c2[nH]nnc2n1
SMILES	OpenEye OEToolkits	1.5.0	c12c(nc(nc1O)N)nn[nH]2
Canonical SMILES	CACTVS	3.341	Nc1nc(O)c2[nH]nnc2n1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c12c(nc(nc1O)N)nn[nH]2
InChI	InChI	1.03	InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
InChIKey	InChI	1.03	LPXQRXLUHJKZIE-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB01667
Name	8-azaguanine
Groups	experimental
Description	8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Synonyms	8 AG 8-azaguanine Azaguanine-8 Pathocidine Azaguanine Guanazol 3-amino-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one Pathocidin
Categories	Antimetabolites Antineoplastic Agents Aza Compounds Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Noxae Purines Purinones Toxic Actions Xanthine derivatives
CAS number	134-58-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Purine nucleoside phosphorylase	MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDY...	unknown
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682