Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.[L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318]
Synonyms
Aciclovirum
Acyclovir sodium
Acyclovir
Acycloguanosine
Aciclovir
Brand Names
Acyclovir-200
Xerese
Apo-acyclovir Ointment
Taro-acyclovir
Sitavig
Zovirax 800
Alti-acyclovir - 400mg
Zovirax
LidoVir
Acyclovir Sodium for Injection
Ntp-acyclovir
Alti-acyclovir - 800mg
Mint-acyclovir
Acyclovir-400
Ratio-acyclovir
Zovirax Cap 200mg
Acyclovir Sodium Injection
Mylan-acyclovir
Zovirax Tab 200mg
Zovirax 400
Alti-acyclovir - Tab 200mg
Acyclovir Sodium
Acyclovix
Apo-acyclovir
Teva-acyclovir
Acyclovir
Acyclovir-800
Acyclovir suspension
Indication
An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older.[L7303] Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox.[L7315] An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients.[L7318] An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older.[L7321] An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis.[L7324] An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.[L7327]
Categories
Acyclovir and prodrug
Anti-Infective Agents
Antiinfectives for Systemic Use
Antiviral Agents
Antivirals for Systemic Use
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 Substrates
Dermatologicals
Direct Acting Antivirals
Drugs that are Mainly Renally Excreted
Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor
Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
Heterocyclic Compounds, Fused-Ring
MATE 1 Substrates
MATE 2 Substrates
MATE substrates
Nephrotoxic agents
Nucleic Acid Synthesis Inhibitors
Nucleosides and Nucleotides
Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
