8MO

METHOXSALEN

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is present as a standalone ligand in 1 entries

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Chemical Component Summary
Name	METHOXSALEN
Synonyms	9-METHOXY-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE
Identifiers	9-methoxypyrano[5,6-f][1]benzoxol-7-one
Formula	C₁₂ H₈ O₄
Molecular Weight	216.19
Type	NON-POLYMER
Isomeric SMILES	COc1c2c(cco2)cc3c1OC(=O)C=C3
InChI	InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChIKey	QXKHYNVANLEOEG-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	15

Drug Info: DrugBank

DrugBank ID	DB00553
Name	Methoxsalen
Groups	approved
Description	A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Synonyms	Metoxaleno 8-methoxy-[furano-3'.2':6.7-coumarin] 8-methoxy-2',3',6,7-furocoumarin Méthoxsalène Methoxsalen 8-MOP 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one Xanthotoxin 6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone 8-MP Ammoidin O-methylxanthotoxol 8-methoxypsoralen 8-Methoxyfuranocoumarin Xanthotoxine 8-methoxy-4',5':6,7-furocoumarin
Brand Names	8-mop Oxsoralen-Ultra Ultramop Cap 10mg Methoxsalen Oxsoralen Cap 10mg Uvadex Oxsoralen-ultra Cap 10mg Oxsoralen Oxsoralen Lot 10mg/ml Ultra Mop Lotion 1%
Indication	For the treatment of psoriasis and vitiligo
Categories	Antipsoriatics Antipsoriatics for Systemic Use Antipsoriatics for Topical Use Benzopyrans Coloring Agents Compounds used in a research, industrial, or household setting Cross-Linking Reagents Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP1A2 Inhibitors (strength unknown) Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Dermatologicals Drugs that are Mainly Renally Excreted Furocoumarins Heterocyclic Compounds, Fused-Ring Indicators and Reagents Laboratory Chemicals Photoabsorption Photoactivated Radical Generator Photosensitizing Activity Photosensitizing Agents Photosensitizing Agents for Phototherapy Psoralens for Systemic Use Psoralens for Topical Use Pyrans Radiation-Sensitizing Agents
ATC-Code	D05BA02 D05AD02
CAS number	298-81-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA	-	unknown	intercalation
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	inhibitor
Cytochrome P450 2A13	MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682