Chemical Component Summary

NamePAMIDRONATE
Synonyms(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
Identifiers(3-amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
FormulaC3 H11 N O7 P2
Molecular Weight235.069
TypeNON-POLYMER
Isomeric SMILESC(CN)C(O)(P(=O)(O)O)P(=O)(O)O
InChIInChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKeyWRUUGTRCQOWXEG-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count24
Chiral Atom Count0
Bond Count23
Aromatic Bond Count0

Drug Info: DrugBank

DrugBank IDDB00282 
NamePamidronic acid
Groups approved
DescriptionPamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Synonyms
  • Acidum pamidronicum
  • Pamidronate
  • Pamidronate Disodium
  • Pamidronic acid
  • Acido pamidronico
Brand Names
  • Pamidronate Disodium
  • PMS-pamidronate
  • Pamidronate Disodium Omega 3 mg/ml
  • Aredia
  • Aredia 30mg
IndicationPamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Categories
  • Agents Causing Muscle Toxicity
  • Antineoplastic Agents
  • Bisphosphonates
  • Bone Density Conservation Agents
  • Drugs Affecting Bone Structure and Mineralization
ATC-CodeM05BA03
CAS number40391-99-9

Drug Targets

NameTarget SequencePharmacological ActionActions
Farnesyl pyrophosphate synthaseMPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...unknowninhibitor
Hydroxylapatite-unknownantagonist
Geranylgeranyl pyrophosphate synthaseMEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIII...unknowninhibitor
Caspase-3MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIII...unknownactivator
Caspase-9MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGS...unknownactivator
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL834
PubChem 44400012, 4674
ChEMBL CHEMBL834
ChEBI CHEBI:7903