Annotations: 9DMY

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF00377	Prion/Doppel alpha-helical domain (Prion)	Prion/Doppel alpha-helical domain	The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the ...	The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Major prion protein	cation binding ion binding binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis	cellular anatomical structure membrane side of membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system

Chains	Accession	Name	Type
A, B, C, D, E	IPR036924	Prion/Doppel beta-ribbon domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR000817	Prion protein	Family
A, B, C, D, E	IPR022416	Prion/Doppel protein, beta-ribbon domain	Domain
A, B, C, D, E	IPR025860	Major prion protein N-terminal domain	Domain