Annotations: 8UA1

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF17862	AAA+ lid domain (AAA_lid_3)	AAA+ lid domain	This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.	Domain
A, B, C, D, E A, B, C, D, E, F	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Cell division control protein 48	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding identical protein binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity ubiquitin binding ubiquitin-like protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process cellular response to misfolded protein response to misfolded protein cellular response to stress modification-dependent macromolecule catabolic process proteolysis response to stress protein metabolic process cellular response to topologically incorrect protein cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process cellular response to misfolded protein response to misfolded protein cellular response to stress modification-dependent macromolecule catabolic process proteolysis response to stress protein metabolic process cellular response to topologically incorrect protein primary metabolic process proteasomal protein catabolic process protein catabolic process nuclear protein quality control by the ubiquitin-proteasome system modification-dependent protein catabolic process response to topologically incorrect protein ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein quality control for misfolded or incompletely synthesized proteins cellular component disassembly cellular response to metal ion protein-containing complex organization protein-containing complex disassembly response to cadmium ion cellular component organization cellular response to chemical stimulus response to metal ion response to chemical cellular response to cadmium ion cellular component organization or biogenesis SCF complex disassembly in response to cadmium stress macroautophagy autophagy autophagosome maturation process utilizing autophagic mechanism spindle disassembly microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization organelle organization mitotic cell cycle process organelle disassembly mitotic spindle disassembly microtubule-based process cell cycle cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process response to nitrogen compound ERAD pathway response to endoplasmic reticulum stress ribosome disassembly rescue of stalled ribosome translation gene expression macromolecule biosynthetic process biosynthetic process translational elongation piecemeal microautophagy of the nucleus microautophagy nucleophagy establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore sister chromatid biorientation chromosome organization sister chromatid segregation establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation establishment of chromosome localization chromosome segregation ribosome-associated ubiquitin-dependent protein catabolic process ribophagy positive regulation of organelle organization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process positive regulation of developmental process anatomical structure development regulation of mitochondrial fusion mitochondrial fusion positive regulation of cellular process regulation of anatomical structure morphogenesis positive regulation of mitochondrial fusion mitochondrion organization developmental process regulation of biological process biological regulation regulation of organelle organization organelle fusion anatomical structure morphogenesis regulation of mitochondrion organization protein localization establishment of protein localization nitrogen compound transport transport establishment of protein localization to plasma membrane vesicle-mediated transport endocytic recycling cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane intracellular transport localization within membrane protein localization to membrane endosomal transport vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport protein transport macromolecule localization intracellular protein transport stress-induced homeostatically regulated protein degradation pathway mitotic DNA replication cell cycle DNA replication termination DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication DNA metabolic process DNA replication termination nucleic acid metabolic process nucleobase-containing compound metabolic process nuclear DNA replication termination DNA replication mitotic DNA replication termination regulation of localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus regulation of cellular localization protein localization to organelle positive regulation of protein localization nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process nucleotide metabolic process purine-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process mitochondria-associated ubiquitin-dependent protein catabolic process nonfunctional rRNA decay RNA metabolic process rRNA catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process rRNA metabolic process RNA catabolic process cytoplasm protein quality control cytoplasm protein quality control by the ubiquitin-proteasome system membrane organization membrane fusion organelle membrane fusion endoplasmic reticulum organization endoplasmic reticulum membrane organization endoplasmic reticulum membrane fusion endomembrane system organization protein exit from endoplasmic reticulum endoplasmic reticulum to cytosol transport retrograde protein transport, ER to cytosol establishment of protein localization to vacuole late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway endosome transport via multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole establishment of protein localization to organelle multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway vacuolar transport	cell projection cellular anatomical structure mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection site of polarized growth intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex cell projection cellular anatomical structure mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection site of polarized growth intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex mitochondrial membrane mitochondrion outer mitochondrial membrane protein complex membrane membrane protein complex organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle Cdc48p-Npl4p-Vms1p AAA ATPase complex organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane cytoplasmic ubiquitin ligase complex ubiquitin ligase complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex Doa10p ubiquitin ligase complex organelle subcompartment endoplasmic reticulum intracellular protein-containing complex VCP-NPL4-UFD1 AAA ATPase complex RQC complex Hrd1p ubiquitin ligase ERAD-L complex Hrd1p ubiquitin ligase complex protein-DNA complex intracellular membraneless organelle chromosome membraneless organelle replication fork replisome nucleus
G	Substrate	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR003959	ATPase, AAA-type, core	Domain
A, B, C, D, E A, B, C, D, E, F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR029067	CDC48 domain 2-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR005938	AAA ATPase, CDC48 family	Family
A, B, C, D, E A, B, C, D, E, F	IPR003338	CDC48, N-terminal subdomain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR004201	CDC48, domain 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR041569	AAA ATPase, AAA+ lid domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR050168	AAA ATPase domain-containing protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR003960	ATPase, AAA-type, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.