5UUZ

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P200

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d5uuzf1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
F	d5uuzf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
H	d5uuzh1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
H	d5uuzh2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
A	d5uuza1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
A	d5uuza2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
B	d5uuzb1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
B	d5uuzb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
C	d5uuzc1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
C	d5uuzc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
D	d5uuzd1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
D	d5uuzd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
E	d5uuze1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
E	d5uuze2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
G	d5uuzg1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Inosine monophosphate dehydrogenase (IMPDH)	automated matches	automated matches	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)
G	d5uuzg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Bacillus anthracis ) [TaxId: 1392 ], (Bacillus anthracis ) [TaxId: 1392 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	IMPDH_1st	e5uuzF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
H	IMPDH_1st	e5uuzH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
A	IMPDH_1st	e5uuzA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
B	IMPDH_1st	e5uuzB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
C	IMPDH_1st	e5uuzC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
D	IMPDH_1st	e5uuzD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
E	IMPDH_1st	e5uuzE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)
G	IMPDH_1st	e5uuzG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: IMPDH_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
H	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
C	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
D	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
E	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
G	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00478	IMP dehydrogenase / GMP reductase domain (IMPDH)	IMP dehydrogenase / GMP reductase domain	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a membe ...	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a member of the common phosphate binding site TIM barrel family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Inosine-5'-monophosphate dehydrogenase	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity IMP dehydrogenase activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding cation binding ion binding metal ion binding	ribose phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process ribose phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process GMP metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process GMP biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process GTP metabolic process GTP biosynthetic process purine ribonucleoside triphosphate biosynthetic process purine nucleoside triphosphate biosynthetic process purine ribonucleoside triphosphate metabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process ribonucleoside triphosphate biosynthetic process nucleoside triphosphate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR046342	CBS domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000644	CBS domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001093	IMP dehydrogenase/GMP reductase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005990	Inosine-5'-monophosphate dehydrogenase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR015875	IMP dehydrogenase / GMP reductase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.