5MZF

Crystal structure of dog MTH1 protein

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5mzfa_	Alpha and beta proteins (a+b)	Nudix	Nudix	MutT-like	automated matches	Dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
C	d5mzfc_	Alpha and beta proteins (a+b)	Nudix	Nudix	MutT-like	automated matches	Dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
B	d5mzfb1	Alpha and beta proteins (a+b)	Nudix	Nudix	MutT-like	automated matches	Dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
B	d5mzfb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nudix	8058806	3000098	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nudix	8058806	3000098	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nudix	8058806	3000098	SCOP2B (2022-06-29)
B	SCOP2 Family	MutT-like	8058805	4001887	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Nudix	8058806	3000098	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NUDIX	e5mzfA1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX	ECOD (1.6)
C	NUDIX	e5mzfC1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX	ECOD (1.6)
B	NUDIX	e5mzfB1	A: a+b two layers	X: beta-Grasp	H: Nudix (From Topology)	T: Nudix	F: NUDIX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (utative)
C	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (utative)
D	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (utative)
B	3.90.79.10	Alpha Beta	Alpha-Beta Complex	Nucleoside Triphosphate Pyrophosphohydrolase	Nucleoside Triphosphate Pyrophosphohydrolase	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00293	NUDIX domain (NUDIX)	NUDIX domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	MTH1 protein	pyrophosphatase activity 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity N6-methyl-(d)ATP hydrolase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity 2-hydroxy-ATP hydrolase activity dATP diphosphatase activity 2-hydroxy-dATP hydrolase activity O6-methyl-dGTP hydrolase activity RNA binding pyrophosphatase activity 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity N6-methyl-(d)ATP hydrolase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity 2-hydroxy-ATP hydrolase activity dATP diphosphatase activity 2-hydroxy-dATP hydrolase activity O6-methyl-dGTP hydrolase activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process purine nucleoside catabolic process carbohydrate derivative metabolic process primary metabolic process glycosyl compound catabolic process purine-containing compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule catabolic process nucleobase-containing small molecule metabolic process nucleoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process purine nucleoside catabolic process carbohydrate derivative metabolic process primary metabolic process glycosyl compound catabolic process purine-containing compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule catabolic process nucleobase-containing small molecule metabolic process nucleoside catabolic process small molecule metabolic process metabolic process cellular process small molecule catabolic process purine nucleoside metabolic process cellular response to stimulus response to stimulus DNA metabolic process nucleic acid metabolic process cellular response to stress response to stress macromolecule metabolic process DNA protection	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope cellular anatomical structure organelle nuclear envelope organelle membrane cytoplasm acrosomal vesicle intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003563	Oxidized purine nucleoside triphosphate	Family
A, B, C, D	IPR000086	NUDIX hydrolase domain	Domain
A, B, C, D	IPR015797	NUDIX hydrolase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR020084	NUDIX hydrolase, conserved site	Conserved Site
A, B, C, D	IPR020476	NUDIX hydrolase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.