4TZC
Crystal Structure of Murine Cereblon in Complex with Thalidomide
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth C] | Yippee-Mis18_1 | e4tzcC1 | A: beta complex topology | X: ETN0001 domain-like (From Homology) | H: ETN0001 domain-like | T: Mss4-like | F: Yippee-Mis18_1 | ECOD (1.6) |
C [auth B] | Yippee-Mis18_1 | e4tzcB1 | A: beta complex topology | X: ETN0001 domain-like (From Homology) | H: ETN0001 domain-like | T: Mss4-like | F: Yippee-Mis18_1 | ECOD (1.6) |
D | Yippee-Mis18_1 | e4tzcD1 | A: beta complex topology | X: ETN0001 domain-like (From Homology) | H: ETN0001 domain-like | T: Mss4-like | F: Yippee-Mis18_1 | ECOD (1.6) |
B [auth A] | Yippee-Mis18_1 | e4tzcA1 | A: beta complex topology | X: ETN0001 domain-like (From Homology) | H: ETN0001 domain-like | T: Mss4-like | F: Yippee-Mis18_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth C] | 2.170.150.20 | Mainly Beta | Beta Complex | Metal Binding Protein, Guanine Nucleotide Exchange Factor | Chain A | CATH (4.3.0) |
C [auth B] | 2.170.150.20 | Mainly Beta | Beta Complex | Metal Binding Protein, Guanine Nucleotide Exchange Factor | Chain A | CATH (4.3.0) |
D | 2.170.150.20 | Mainly Beta | Beta Complex | Metal Binding Protein, Guanine Nucleotide Exchange Factor | Chain A | CATH (4.3.0) |
B [auth A] | 2.170.150.20 | Mainly Beta | Beta Complex | Metal Binding Protein, Guanine Nucleotide Exchange Factor | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth C], B [auth A], C [auth B], D | PF03226 | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly (Yippee-Mis18) | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly | This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth C], B [auth A], C [auth B], D | IPR015947 | PUA-like superfamily | Homologous Superfamily |
A [auth C], B [auth A], C [auth B], D | IPR046336 | Lon protease, N-terminal domain superfamily | Homologous Superfamily |
A [auth C], B [auth A], C [auth B], D | IPR004910 | Yippee/Mis18/Cereblon | Domain |
A [auth C], B [auth A], C [auth B], D | IPR003111 | Lon protease, N-terminal domain | Domain |
A [auth C], B [auth A], C [auth B], D | IPR034750 | CULT domain | Domain |