4KTR

Crystal structure of 2-O-alpha-glucosylglycerol phosphorylase in complex with isofagomine and glycerol

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_65N	e4ktrA1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
A	Glyco_hydro_65C	e4ktrA3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
A	UNK_F_TYPE	e4ktrA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
D	Glyco_hydro_65N	e4ktrD1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
D	Glyco_hydro_65C	e4ktrD3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
D	UNK_F_TYPE	e4ktrD2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
B	Glyco_hydro_65N	e4ktrB1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
B	Glyco_hydro_65C	e4ktrB3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
B	UNK_F_TYPE	e4ktrB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
C	Glyco_hydro_65N	e4ktrC1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
C	Glyco_hydro_65C	e4ktrC3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
C	UNK_F_TYPE	e4ktrC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
E	Glyco_hydro_65N	e4ktrE1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
E	Glyco_hydro_65C	e4ktrE3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
E	UNK_F_TYPE	e4ktrE2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
F	Glyco_hydro_65N	e4ktrF1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
F	Glyco_hydro_65C	e4ktrF3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
F	UNK_F_TYPE	e4ktrF2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
G	Glyco_hydro_65N	e4ktrG1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
G	Glyco_hydro_65C	e4ktrG3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
G	UNK_F_TYPE	e4ktrG2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)
H	Glyco_hydro_65N	e4ktrH1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Glyco_hydro_65N	ECOD (1.6)
H	Glyco_hydro_65C	e4ktrH3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycoside hydrolase family 127 middle domain-related (From Topology)	T: Glycoside hydrolase family 127 middle domain-related	F: Glyco_hydro_65C	ECOD (1.6)
H	UNK_F_TYPE	e4ktrH2	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
A	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
A	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
D	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
D	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
D	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
B	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
B	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
B	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
C	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
C	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
C	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
E	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
E	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
E	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
F	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
F	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
F	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
G	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
G	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
G	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)
H	2.70.98.40	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
H	2.60.420.10	Mainly Beta	Sandwich	Maltose phosphorylase, domain 3	Maltose phosphorylase, domain 3	CATH (4.3.0)
H	1.50.10.10	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF03636	Glycosyl hydrolase family 65, N-terminal domain (Glyco_hydro_65N)	Glycosyl hydrolase family 65, N-terminal domain	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H	PF03632	Glycosyl hydrolase family 65 central catalytic domain (Glyco_hydro_65m)	Glycosyl hydrolase family 65 central catalytic domain	-	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H	PF03633	Glycosyl hydrolase family 65, C-terminal domain (Glyco_hydro_65C)	Glycosyl hydrolase family 65, C-terminal domain	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucos ...	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The C-terminal domain forms a two layered jelly roll motif. This domain is situated at the base of the catalytic domain, however its function remains unknown [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Glycoside hydrolase family 65 central catalytic	binding carbohydrate binding glycosyltransferase activity transferase activity catalytic activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity cation binding ion binding metal ion binding small molecule binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR037018	Glycoside hydrolase family 65, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005195	Glycoside hydrolase, family 65, central catalytic	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005194	Glycoside hydrolase family 65, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR017045	Maltose phosphorylase/glycosyl hydrolase/vacuolar acid trehalase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011013	Galactose mutarotase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005196	Glycoside hydrolase, family 65, N-terminal	Domain