3VVA

Crystal structure of cyanide-insensitive alternative oxidase from Trypanosoma brucei with ascofuranone derivative

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ferritin-like	8052478	3001658	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ferritin-like	8052478	3001658	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ferritin-like	8052478	3001658	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ferritin-like	8052478	3001658	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AOX	e3vvaA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Ferritin	F: AOX	ECOD (1.6)
B	AOX	e3vvaB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Ferritin	F: AOX	ECOD (1.6)
C	AOX	e3vvaC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Ferritin	F: AOX	ECOD (1.6)
D	AOX	e3vvaD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Ferritin	F: AOX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1260.140	Mainly Alpha	Up-down Bundle	Ferritin	Alternative oxidase	CATH (4.3.0)
B	1.20.1260.140	Mainly Alpha	Up-down Bundle	Ferritin	Alternative oxidase	CATH (4.3.0)
C	1.20.1260.140	Mainly Alpha	Up-down Bundle	Ferritin	Alternative oxidase	CATH (4.3.0)
D	1.20.1260.140	Mainly Alpha	Up-down Bundle	Ferritin	Alternative oxidase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01786	Alternative oxidase (AOX)	Alternative oxidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Alternative oxidase, mitochondrial	oxidoreductase activity catalytic activity cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor alternative oxidase activity oxidoreductase activity, acting on diphenols and related substances as donors	alternative respiration aerobic respiration cellular respiration energy derivation by oxidation of organic compounds metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002680	Alternative oxidase	Family
A, B, C, D	IPR038659	Alternative oxidase superfamily	Homologous Superfamily

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	MONOTOPIC MEMBRANE PROTEINS	Oxidases	Alternative oxidase (AOX), cyanide-insensitive

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.