3R76

Crystal structure of 2-amino-2-desoxyisochorismate synthase (ADIC) synthase PhzE from Burkholderia lata 383 in complex with benzoate, pyruvate and glutamine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Chorismate_bind	e3r76B4	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: Chorismate_bind	ECOD (1.6)
B	GATase	e3r76B3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)
A	Chorismate_bind	e3r76A1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: Chorismate_bind	ECOD (1.6)
A	GATase	e3r76A2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Class I glutamine amidotransferase-like	F: GATase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)
B	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)
A	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)
A	3.40.50.880	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Class I glutamine amidotransferase (GATase) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	-	Family
A, B	PF00117	Glutamine amidotransferase class-I (GATase)	Glutamine amidotransferase class-I	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Anthranilate/para-aminobenzoate synthases component I	cation binding ion binding binding metal ion binding small molecule binding oxo-acid-lyase activity lyase activity anthranilate synthase activity catalytic activity carbon-carbon lyase activity	glutamine metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029062	Class I glutamine amidotransferase-like	Homologous Superfamily
A, B	IPR019999	Anthranilate synthase component I-like	Family
A, B	IPR017926	Glutamine amidotransferase	Domain
A, B	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
A, B	IPR005801	ADC synthase	Homologous Superfamily
A, B	IPR006221	Anthranilate synthase/para-aminobenzoate synthase like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.