Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3nifa_ All beta proteins 7-bladed beta-propeller Integrin alpha N-terminal domain Integrin alpha N-terminal domain Integrin alpha N-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Cd3nifc_ All beta proteins 7-bladed beta-propeller Integrin alpha N-terminal domain Integrin alpha N-terminal domain Integrin alpha N-terminal domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed3nife_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
G [auth H]d3nifh_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Fd3niff2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
Fd3niff1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
H [auth L]d3nifl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)
H [auth L]d3nifl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyIntegrin alpha N-terminal domain 8042728 3000314 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyIntegrin alpha N-terminal domain 8042728 3000314 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyvWA-like 8055554 3000832 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPlexin repeat-like 8042732 3000415 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPlexin repeat-like 8042732 3000415 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyvWA-like 8055554 3000832 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyIntegrin domains 8055552 3002062 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFG-GAP_1ste3nifA1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: FG-GAP_1stECOD (1.6)
CFG-GAP_1ste3nifC1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: FG-GAP_1stECOD (1.6)
BINBe3nifB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: INBECOD (1.6)
BIntegrin_betae3nifB2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: vWA-likeF: Integrin_betaECOD (1.6)
BPSI_integrine3nifB3 A: few secondary structure elementsX: Trefoil/Plexin domain-like (From Topology)H: Trefoil/Plexin domain-like (From Topology)T: Trefoil/Plexin domain-likeF: PSI_integrinECOD (1.6)
DINBe3nifD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: INBECOD (1.6)
DIntegrin_betae3nifD2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: vWA-likeF: Integrin_betaECOD (1.6)
DPSI_integrine3nifD3 A: few secondary structure elementsX: Trefoil/Plexin domain-like (From Topology)H: Trefoil/Plexin domain-like (From Topology)T: Trefoil/Plexin domain-likeF: PSI_integrinECOD (1.6)
DKOG1226_1ste3nifD4 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: KOG1226_1stECOD (1.6)
EV-set_8e3nifE2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
EC1-set_1e3nifE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
G [auth H]V-set_8e3nifH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
G [auth H]C1-set_1e3nifH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
FC1-set_4e3nifF2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
FV-sete3nifF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
H [auth L]C1-set_4e3nifL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
H [auth L]V-sete3nifL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A, C
INTEGRIN-ALPHA-IIB_BETA-3 INTEGRIN-ALPHA-IIB Homo sapiens (human) ALPHA-IIB A-LIKE-DOMAIN B-Propeller RPI INTEGRIN-ALPHA-IIB_BETA-3 IMGT (202448-0)
B, D
INTEGRIN-ALPHA-IIB_BETA-3 INTEGRIN-BETA-3 Homo sapiens (human) BETA-3 P-LIKE-DOMAIN PSI, Y-LIKE-DOMAIN Hybrid-1, B-LIKE-DOMAIN BETA-1, Y-LIKE-DOMAIN Hybrid-2, E-LIKE-DOMAIN EGF-1 RPI INTEGRIN-ALPHA-IIB_BETA-3 IMGT (202448-0)
E,
G [auth H]
10E5 VH-CH1 Mus musculus (house mouse) IGHV14-3*02, IGHJ4*01, IGHG2A*01, IGHG2A*02 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-2A_KAPPA IMGT (202448-0)
F,
H [auth L]
10E5 L-KAPPA Mus musculus (house mouse) IGKV14-100*01, IGKJ2*01, IGKC*01, IGKC*02 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-2A_KAPPA IMGT (202448-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
E,
G [auth H]
Heavy ChainIGHV14 -integrin alphaiib beta3, integrin alphaiib beta3 | integrin beta-3SAbDab (2024-12-06)
F,
H [auth L]
Light ChainIGKV14 Kappaintegrin alphaiib beta3, integrin alphaiib beta3 | integrin beta-3SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF01839FG-GAP repeat (FG-GAP)FG-GAP repeat- Repeat
B, D
PF18372Integrin beta epidermal growth factor like domain 1 (I-EGF_1)Integrin beta epidermal growth factor like domain 1This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2 [1]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 do ...This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2 [1]. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end [14].
Domain
B, D
PF17205Integrin plexin domain (PSI_integrin)Integrin plexin domainThis short disulphide rich domain is found at the N-terminus of integrin beta chains.Domain
B, D
PF00362Integrin beta chain VWA domain (Integrin_beta)Integrin beta chain VWA domainIntegrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Integrin alphaIIB beta3
B, D
Integrin beta-3
E,
G [auth H]
Monoclonal antibody 10E5 heavy chain---
F,
H [auth L]
Monoclonal antibody 10E5 light chain---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C
PharosP08514
B, D
PharosP05106