Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyType II DNA topoisomerase half-clamp domain-like 8037554 3001800 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyWinged helix DNA-binding domain 8055747 3000034 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyToprim domain-like 8055749 3000737 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADNA_topoisoIV_1ste3l4jA3 A: alpha arraysX: HTHH: HTHT: wingedF: DNA_topoisoIV_1stECOD (1.6)
ADNA_topoisoIV_3rde3l4jA5 A: alpha bundlesX: alpha-helical domain in type II DNA topoisomerase (From Topology)H: alpha-helical domain in type II DNA topoisomerase (From Topology)T: alpha-helical domain in type II DNA topoisomeraseF: DNA_topoisoIV_3rdECOD (1.6)
ATOPRIM_Ce3l4jA1 A: a+b two layersX: SSHS domainH: SSHS domain in type II DNA topoisomerase (From Topology)T: SSHS domain in type II DNA topoisomeraseF: TOPRIM_CECOD (1.6)
ADNA_topoisoIV_2nd_1e3l4jA4 A: a+b two layersX: a+b domain in type II DNA topoisomerase (From Topology)H: a+b domain in type II DNA topoisomerase (From Topology)T: a+b domain in type II DNA topoisomeraseF: DNA_topoisoIV_2nd_1ECOD (1.6)
ADNA_gyraseB_Ce3l4jA2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: Toprim domainF: DNA_gyraseB_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.670 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
A3.30.1490.30 Alpha Beta 2-Layer Sandwich Dna Ligase domain 1CATH (4.3.0)
A3.90.199.10 Alpha Beta Alpha-Beta Complex Topoisomerase II domain 5CATH (4.3.0)
A3.30.1360.40 Alpha Beta 2-Layer Sandwich Gyrase A domain 2CATH (4.3.0)
A1.10.268.10 Mainly Alpha Orthogonal Bundle Topoisomerase domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01751Toprim domain (Toprim)Toprim domain- Family
PF16898C-terminal associated domain of TOPRIM (TOPRIM_C)C-terminal associated domain of TOPRIM- Family
PF00521DNA gyrase/topoisomerase IV, subunit A (DNA_topoisoIV)DNA gyrase/topoisomerase IV, subunit A- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
DNA topoisomerase 2
DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3')---
DNA (5'-D(P*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*)-3')---
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3')---
DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3')---

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048