Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CC1-set_1e3csyC2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
CV-set_12e3csyC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
EC1-set_1e3csyE2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
EV-set_12e3csyE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
GC1-set_1e3csyG2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
GV-set_12e3csyG1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
AC1-set_1e3csyA2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
AV-set_12e3csyA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
FC1-set_4e3csyF2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
FV-sete3csyF1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
HC1-set_4e3csyH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
HV-sete3csyH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
BC1-set_4e3csyB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
BV-sete3csyB1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
DC1-set_4e3csyD2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
DV-sete3csyD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
IFilo_glycope3csyI1 A: a+b complex topologyX: Envelope glycoprotein GP1 (From Topology)H: Envelope glycoprotein GP1 (From Topology)T: Envelope glycoprotein GP1F: Filo_glycopECOD (1.6)
KFilo_glycope3csyK1 A: a+b complex topologyX: Envelope glycoprotein GP1 (From Topology)H: Envelope glycoprotein GP1 (From Topology)T: Envelope glycoprotein GP1F: Filo_glycopECOD (1.6)
OFilo_glycope3csyO1 A: a+b complex topologyX: Envelope glycoprotein GP1 (From Topology)H: Envelope glycoprotein GP1 (From Topology)T: Envelope glycoprotein GP1F: Filo_glycopECOD (1.6)
MFilo_glycope3csyM1 A: a+b complex topologyX: Envelope glycoprotein GP1 (From Topology)H: Envelope glycoprotein GP1 (From Topology)T: Envelope glycoprotein GP1F: Filo_glycopECOD (1.6)
JEbola-like_HR1-HR2e3csyJ1 A: a+b duplicates or obligate multimersX: Envelope glycoprotein GP2-related (From Topology)H: Envelope glycoprotein GP2-related (From Topology)T: Envelope glycoprotein GP2-relatedF: Ebola-like_HR1-HR2ECOD (1.6)
LEbola-like_HR1-HR2e3csyL1 A: a+b duplicates or obligate multimersX: Envelope glycoprotein GP2-related (From Topology)H: Envelope glycoprotein GP2-related (From Topology)T: Envelope glycoprotein GP2-relatedF: Ebola-like_HR1-HR2ECOD (1.6)
NEbola-like_HR1-HR2e3csyN1 A: a+b duplicates or obligate multimersX: Envelope glycoprotein GP2-related (From Topology)H: Envelope glycoprotein GP2-related (From Topology)T: Envelope glycoprotein GP2-relatedF: Ebola-like_HR1-HR2ECOD (1.6)
PEbola-like_HR1-HR2e3csyP1 A: a+b duplicates or obligate multimersX: Envelope glycoprotein GP2-related (From Topology)H: Envelope glycoprotein GP2-related (From Topology)T: Envelope glycoprotein GP2-relatedF: Ebola-like_HR1-HR2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
E2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
G2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
A2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
F2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
H2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A, C, E, G
Fab KZ52 VH-CH1 Homo sapiens (human) IGHV3-21*01, IGHV3-21*02, IGHV3-21*04, IGHV3-21*03, IGHJ3*02, IGHG1*01, IGHG1*02, IGHG1*04 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202448-0)
B, D, F, H
Fab KZ52 L-KAPPA Homo sapiens (human) IGKV4-1*01, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202448-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A, C, E, G
Heavy ChainIGHV3 -envelope glycoprotein gp2 | envelope glycoprotein gp1SAbDab (2024-12-06)
B, D, F, H
Light ChainIGKV4 Kappaenvelope glycoprotein gp2 | envelope glycoprotein gp1SAbDab (2024-12-06)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
I, K, M, O
PF01611Filovirus glycoprotein (Filo_glycop)Filovirus glycoprotein- Family
J, L, N, P
PF22307Envelope glycoprotein GP2-like, HR1-HR2 (Ebola-like_HR1-HR2)Envelope glycoprotein GP2-like, HR1-HR2This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel ...This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [1-5]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel orientation). This domain may have been acquired via horizontal transfer from retroviruses.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G
Fab KZ52 heavy chain---
B, D, F, H
Fab KZ52 light chain---
I, K, M, O
Envelope glycoprotein GP1
J, L, N, P
Envelope glycoprotein GP2