2VYV
Structure of E.Coli GAPDH Rat Sperm GAPDH heterotetramer
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
D | SCOP2B Superfamily | GAPDH-like | 8068867 | 3000043 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | GAPDH-like | 8000884 | 3000043 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | GAPDH-like | 8000884 | 3000043 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | GAPDH-like | 8000884 | 3000043 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D | Gp_dh_C | e2vyvD1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
D | Gp_dh_N_2 | e2vyvD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
A | Gp_dh_C | e2vyvA1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
A | Gp_dh_N_2 | e2vyvA2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
B | Gp_dh_C | e2vyvB1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
B | Gp_dh_N_2 | e2vyvB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
C | Gp_dh_C | e2vyvC1 | A: a+b two layers | X: FwdE/GAPDH domain-like | H: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology) | T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain | F: Gp_dh_C | ECOD (1.6) |
C | Gp_dh_N_2 | e2vyvC2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: Gp_dh_N_2 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
D | 3.30.360.10 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 3.30.360.10 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
B | 3.30.360.10 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
C | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
C | 3.30.360.10 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (Gp_dh_C) | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold. | Domain | |
PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (Gp_dh_N) | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold. | Domain | |
PF02800 | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (Gp_dh_C) | Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold. | Domain | |
PF00044 | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (Gp_dh_N) | Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain | GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
CSD | Parent Component: CYS :  AA0262 :  L-cysteine sulfinic acid MOD:00267 | |
CSX | Parent Component: CYS :  AA0262 , AA0451 :  L-cysteine sulfinic acid MOD:00267 , 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide MOD:01380 | |
CSD | Parent Component: CYS :  AA0262 , AA0451 , AA0262 :  L-cysteine sulfinic acid MOD:00267 , 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide MOD:01380 , L-cysteine sulfinic acid MOD:00267 |