2PC6

Crystal structure of putative acetolactate synthase- small subunit from Nitrosomonas europaea

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2pc6a1	Alpha and beta proteins (a+b)	Ferredoxin-like	ACT-like	IlvH-like	Acetolactate synthase small subunit, IlvH	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)
A	d2pc6a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)
B	d2pc6b1	Alpha and beta proteins (a+b)	Ferredoxin-like	ACT-like	IlvH-like	Acetolactate synthase small subunit, IlvH	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)
C	d2pc6c1	Alpha and beta proteins (a+b)	Ferredoxin-like	ACT-like	IlvH-like	Acetolactate synthase small subunit, IlvH	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)
C	d2pc6c3	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)
D	d2pc6d1	Alpha and beta proteins (a+b)	Ferredoxin-like	ACT-like	IlvH-like	Acetolactate synthase small subunit, IlvH	(Nitrosomonas europaea ATCC 19718 ) [TaxId: 228410 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	IlvH-like	8070010	4000264	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ACT-like	8070011	3000006	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ACT-like	8089681	3000006	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ACT-like	8070011	3000006	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ACT-like	8089681	3000006	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ACT-like	8070011	3000006	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ACT-like	8089681	3000006	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ACT-like	8070011	3000006	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ACT-like	8089681	3000006	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ALS_ss_C	e2pc6A2	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ALS_ss_C	ECOD (1.6)
A	ACT_5	e2pc6A1	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ACT_5	ECOD (1.6)
B	ALS_ss_C	e2pc6B2	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ALS_ss_C	ECOD (1.6)
B	ACT_5	e2pc6B1	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ACT_5	ECOD (1.6)
C	ALS_ss_C	e2pc6C2	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ALS_ss_C	ECOD (1.6)
C	ACT_5	e2pc6C1	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ACT_5	ECOD (1.6)
D	ALS_ss_C	e2pc6D2	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ALS_ss_C	ECOD (1.6)
D	ACT_5	e2pc6D1	A: a+b two layers	X: Alpha-beta plaits	H: ACT-like (From Topology)	T: ACT-like	F: ACT_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
A	3.30.70.1150	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT-like. Chain A, domain 2	CATH (4.3.0)
B	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
B	3.30.70.1150	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT-like. Chain A, domain 2	CATH (4.3.0)
C	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
C	3.30.70.1150	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT-like. Chain A, domain 2	CATH (4.3.0)
D	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
D	3.30.70.1150	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT-like. Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF22629	AHAS small subunit-like ACT domain (ACT_AHAS_ss)	AHAS-like ACT domain	This entry represents the ACT domain found at the N-terminal of acetohydroxyacid synthase isozyme III from Escherichia coli and similar sequences.	Domain
A, B, C, D	PF10369	Small subunit of acetolactate synthase (ALS_ss_C)	Small subunit of acetolactate synthase	ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase. Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in bran ...	ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase. Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in branched-chain amino acid biosynthesis. This reaction is sensitive to certain herbicides [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Probable acetolactate synthase isozyme III (Small subunit)	enzyme regulator activity acetolactate synthase regulator activity molecular function regulator activity transketolase or transaldolase activity transferase activity acetolactate synthase activity catalytic activity lyase activity cation binding ion binding binding metal ion binding small molecule binding	oxoacid metabolic process small molecule biosynthetic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process amino acid biosynthetic process biosynthetic process isoleucine biosynthetic process branched-chain amino acid biosynthetic process metabolic process oxoacid metabolic process small molecule biosynthetic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process amino acid biosynthetic process biosynthetic process isoleucine biosynthetic process branched-chain amino acid biosynthetic process metabolic process cellular process small molecule metabolic process branched-chain amino acid metabolic process isoleucine metabolic process alpha-amino acid biosynthetic process pyruvate family amino acid metabolic process pyruvate family amino acid biosynthetic process L-amino acid biosynthetic process L-valine biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process proteinogenic amino acid biosynthetic process valine metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004789	Acetolactate synthase, small subunit	Family
A, B, C, D	IPR027271	Acetolactate synthase/Transcription factor NikR, C-terminal	Homologous Superfamily
A, B, C, D	IPR045865	ACT-like domain	Homologous Superfamily
A, B, C, D	IPR002912	ACT domain	Domain
A, B, C, D	IPR039557	AHAS, ACT domain	Domain
A, B, C, D	IPR054480	Acetolactate synthase small subunit-like, ACT domain	Domain
A, B, C, D	IPR019455	Acetolactate synthase, small subunit, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.