2IB7
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Thiolase_C | e2ib7B2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
B | Thiolase_N | e2ib7B1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
C | Thiolase_C | e2ib7C2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
C | Thiolase_N | e2ib7C1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
D | Thiolase_C | e2ib7D2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
D | Thiolase_N | e2ib7D1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
A | Thiolase_C | e2ib7A2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
A | Thiolase_N | e2ib7A1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
C | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
D | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
A | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02803 | Thiolase, C-terminal domain (Thiolase_C) | Thiolase, C-terminal domain | Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. | Domain | |
PF00108 | Thiolase, N-terminal domain (Thiolase_N) | Thiolase, N-terminal domain | Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR002155 | Thiolase | Family | |
IPR020617 | Thiolase, C-terminal | Domain | |
IPR020613 | Thiolase, conserved site | Conserved Site | |
IPR016039 | Thiolase-like | Homologous Superfamily | |
IPR020616 | Thiolase, N-terminal | Domain | |
IPR020610 | Thiolase, active site | Active Site | |
IPR020615 | Thiolase, acyl-enzyme intermediate active site | Active Site |