2BRP
Crystal structure of S. pneumoniae hyaluronate lyase in complex with W249b
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d2brpa1 | All alpha proteins | alpha/alpha toroid | Chondroitin AC/alginate lyase | Hyaluronate lyase-like catalytic, N-terminal domain | Hyaluronate lyase | (Streptococcus pneumoniae ) [TaxId: 1313 ], | SCOPe (2.08) |
A | d2brpa2 | All beta proteins | Hyaluronate lyase-like, C-terminal domain | Hyaluronate lyase-like, C-terminal domain | Hyaluronate lyase-like, C-terminal domain | Hyaluronate lyase | (Streptococcus pneumoniae ) [TaxId: 1313 ], | SCOPe (2.08) |
A | d2brpa3 | All beta proteins | Supersandwich | Galactose mutarotase-like | Hyaluronate lyase-like, central domain | Hyaluronate lyase | (Streptococcus pneumoniae ) [TaxId: 1313 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Galactose mutarotase-like | 8043661 | 3000035 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Hyaluronate lyase-like, C-terminal domain | 8043659 | 3001435 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Chondroitin AC/alginate lyase | 8043658 | 3001005 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Lyase_8_C_1 | e2brpA1 | A: beta sandwiches | X: Glycosyl hydrolase domain-like | H: Hyaluronate lyase-like, C-terminal domain (From Topology) | T: Hyaluronate lyase-like, C-terminal domain | F: Lyase_8_C_1 | ECOD (1.6) |
A | Lyase_8 | e2brpA2 | A: beta sandwiches | X: Glycosyl hydrolase domain-like | H: supersandwich (From Topology) | T: supersandwich | F: Lyase_8 | ECOD (1.6) |
A | Lyase_8_N | e2brpA3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: alpha/alpha toroid (From Topology) | T: alpha/alpha toroid | F: Lyase_8_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.50.10.100 | Mainly Alpha | Alpha/alpha barrel | Glycosyltransferase | Chondroitin AC/alginate lyase | CATH (4.3.0) |
A | 2.70.98.10 | Mainly Beta | Distorted Sandwich | Beta-galactosidase | Chain A, domain 5 | CATH (4.3.0) |
A | 2.60.220.10 | Mainly Beta | Sandwich | Chondroitinase Ac | Chain A, domain 3 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08124 | Polysaccharide lyase family 8, N terminal alpha-helical domain (Lyase_8_N) | Polysaccharide lyase family 8, N terminal alpha-helical domain | - | Repeat | |
PF02278 | Polysaccharide lyase family 8, super-sandwich domain (Lyase_8) | Polysaccharide lyase family 8, super-sandwich domain | - | Family | |
PF02884 | Polysaccharide lyase family 8, C-terminal beta-sandwich domain (Lyase_8_C) | Polysaccharide lyase family 8, C-terminal beta-sandwich domain | This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
HYALURONATE LYASE |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR011071 | Polysaccharide lyase family 8-like, C-terminal | Homologous Superfamily | |
IPR008979 | Galactose-binding-like domain superfamily | Homologous Superfamily | |
IPR023295 | Hyaluronate lyase, beta-sheet domain superfamily | Homologous Superfamily | |
IPR012970 | Polysaccharide lyase 8, N-terminal alpha-helical | Domain | |
IPR004103 | Polysaccharide lyase family 8, C-terminal | Domain | |
IPR014756 | Immunoglobulin E-set | Homologous Superfamily | |
IPR038970 | Polysaccharide lyase 8 | Family | |
IPR054563 | Hyaluronate lyase-like, N-terminal | Domain | |
IPR003159 | Polysaccharide lyase family 8, central domain | Domain | |
IPR008929 | Chondroitin AC/alginate lyase | Homologous Superfamily | |
IPR014718 | Glycoside hydrolase-type carbohydrate-binding | Homologous Superfamily | |
IPR048734 | Hyaluronate lyase, N-terminal beta-sheet domain | Domain | |
IPR011013 | Galactose mutarotase-like domain superfamily | Homologous Superfamily | |
IPR019931 | LPXTG cell wall anchor domain | Domain |