1W3Y

Crystal structure of S. pneumoniae hyaluronate lyase in complex with palmitoyl-vitamin C

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1w3ya1	All alpha proteins	alpha/alpha toroid	Chondroitin AC/alginate lyase	Hyaluronate lyase-like catalytic, N-terminal domain	Hyaluronate lyase	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)
A	d1w3ya2	All beta proteins	Hyaluronate lyase-like, C-terminal domain	Hyaluronate lyase-like, C-terminal domain	Hyaluronate lyase-like, C-terminal domain	Hyaluronate lyase	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)
A	d1w3ya3	All beta proteins	Supersandwich	Galactose mutarotase-like	Hyaluronate lyase-like, central domain	Hyaluronate lyase	(Streptococcus pneumoniae ) [TaxId: 1313 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Hyaluronate lyase-like, C-terminal domain	8043659	3001435	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Chondroitin AC/alginate lyase	8043658	3001005	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Galactose mutarotase-like	8043661	3000035	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lyase_8_C_1	e1w3yA1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Hyaluronate lyase-like, C-terminal domain (From Topology)	T: Hyaluronate lyase-like, C-terminal domain	F: Lyase_8_C_1	ECOD (1.6)
A	Lyase_8	e1w3yA2	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Lyase_8	ECOD (1.6)
A	Lyase_8_N	e1w3yA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: Lyase_8_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.98.10	Mainly Beta	Distorted Sandwich	Beta-galactosidase	Chain A, domain 5	CATH (4.3.0)
A	1.50.10.100	Mainly Alpha	Alpha/alpha barrel	Glycosyltransferase	Chondroitin AC/alginate lyase	CATH (4.3.0)
A	2.60.220.10	Mainly Beta	Sandwich	Chondroitinase Ac	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08124	Polysaccharide lyase family 8, N terminal alpha-helical domain (Lyase_8_N)	Polysaccharide lyase family 8, N terminal alpha-helical domain	-	Repeat
A	PF02278	Polysaccharide lyase family 8, super-sandwich domain (Lyase_8)	Polysaccharide lyase family 8, super-sandwich domain	-	Family
A	PF02884	Polysaccharide lyase family 8, C-terminal beta-sandwich domain (Lyase_8_C)	Polysaccharide lyase family 8, C-terminal beta-sandwich domain	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HYALURONATE LYASE	binding carbohydrate binding hyaluronate lyase activity lyase activity carbon-oxygen lyase activity, acting on polysaccharides catalytic activity carbon-oxygen lyase activity	carbohydrate metabolic process primary metabolic process metabolic process cellular process catabolic process	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011071	Polysaccharide lyase family 8-like, C-terminal	Homologous Superfamily
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR023295	Hyaluronate lyase, beta-sheet domain superfamily	Homologous Superfamily
A	IPR012970	Polysaccharide lyase 8, N-terminal alpha-helical	Domain
A	IPR004103	Polysaccharide lyase family 8, C-terminal	Domain
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR038970	Polysaccharide lyase 8	Family
A	IPR054563	Hyaluronate lyase-like, N-terminal	Domain
A	IPR003159	Polysaccharide lyase family 8, central domain	Domain
A	IPR008929	Chondroitin AC/alginate lyase	Homologous Superfamily
A	IPR014718	Glycoside hydrolase-type carbohydrate-binding	Homologous Superfamily
A	IPR048734	Hyaluronate lyase, N-terminal beta-sheet domain	Domain
A	IPR011013	Galactose mutarotase-like domain superfamily	Homologous Superfamily
A	IPR019931	LPXTG cell wall anchor domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.