1OAY

Antibody multispecificity mediated by conformational diversity

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth H]	d1oayh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin heavy chain variable domain, VH	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B [auth J]	d1oayj_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin heavy chain variable domain, VH	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C [auth L]	d1oayl_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain lambda variable domain, VL-lambda	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth M]	d1oaym_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain lambda variable domain, VL-lambda	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E [auth N]	d1oayn_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain lambda variable domain, VL-lambda	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F [auth O]	d1oayo_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain lambda variable domain, VL-lambda	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	V-set_10	e1oayH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_10	ECOD (1.6)
B [auth J]	V-set_10	e1oayJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_10	ECOD (1.6)
C [auth L]	V-set_3	e1oayL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
D [auth M]	V-set_3	e1oayM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
E [auth N]	V-set_3	e1oayN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
F [auth O]	V-set_3	e1oayO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B [auth J]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth N]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth O]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth H], B [auth J]	SPE-7 Fv, anti-2,4-dinitrophenyl (DNP) IgE antibody SPE-7	VH	Mus musculus (house mouse)	IGHV1-7201, IGHJ201	V-DOMAIN VH	IG	FV-HEAVY_LAMBDA	IMGT (202447-0)
C [auth L], D [auth M], E [auth N], F [auth O]	SPE-7 Fv, anti-2,4-dinitrophenyl (DNP) IgE antibody SPE-7	V-LAMBDA	Mus musculus (house mouse)	IGLV101, IGLJ101	V-DOMAIN V-LAMBDA	IG	FV-HEAVY_LAMBDA	IMGT (202447-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], B [auth J]	Heavy Chain	IGHV1	-	FURAZOLIDONE	SAbDab (2024-11-29)
C [auth L], D [auth M], E [auth N], F [auth O]			-	FURAZOLIDONE	undefined (undefined)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth L], D [auth M], E [auth N], F [auth O]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], B [auth J]	IMMUNOGLOBULIN E	-	-	-
C [auth L], D [auth M], E [auth N], F [auth O]	IMMUNOGLOBULIN E	-	response to stimulus immune response immune system process adaptive immune response	protein-containing complex immunoglobulin complex cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth L], D [auth M], E [auth N], F [auth O]	IPR050150	Immunoglobulin Variable Light Chain	Family
C [auth L], D [auth M], E [auth N], F [auth O]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth L], D [auth M], E [auth N], F [auth O]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth L], D [auth M], E [auth N], F [auth O]	IPR013106	Immunoglobulin V-set domain	Domain
C [auth L], D [auth M], E [auth N], F [auth O]	IPR003599	Immunoglobulin domain subtype	Domain
C [auth L], D [auth M], E [auth N], F [auth O]	IPR007110	Immunoglobulin-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.