1N9G

Mitochondrial 2-enoyl thioester reductase Etr1p/Etr2p heterodimer from Candida tropicalis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1n9gc1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
C	d1n9gc2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
F	d1n9gf1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
F	d1n9gf2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
A	d1n9ga1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
A	d1n9ga2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
B	d1n9gb1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
B	d1n9gb2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
D	d1n9gd1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
D	d1n9gd2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
E	d1n9ge1	All beta proteins	GroES-like	GroES-like	Alcohol dehydrogenase-like, N-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)
E	d1n9ge2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Alcohol dehydrogenase-like, C-terminal domain	2,4-dienoyl-CoA reductase	(Candida tropicalis ) [TaxId: 5482 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057565	3000040	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8057564	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroES-like	8057564	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057565	3000040	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Zinc-containing alcohol dehydrogenase-like	8057565	3000040	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroES-like	8057564	3000002	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	ADH_N	e1n9gC1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
C	ADH_zinc_N	e1n9gC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
F	ADH_N	e1n9gF1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
F	ADH_zinc_N	e1n9gF2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
A	ADH_N	e1n9gA1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
A	ADH_zinc_N	e1n9gA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
B	ADH_N	e1n9gB1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
B	ADH_zinc_N	e1n9gB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
D	ADH_N	e1n9gD1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
D	ADH_zinc_N	e1n9gD2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)
E	ADH_N	e1n9gE1	A: beta barrels	X: GroES-like	H: GroES-related	T: Alcohol dehydrogenase-like, N-terminal domain	F: ADH_N	ECOD (1.6)
E	ADH_zinc_N	e1n9gE2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: ADH_zinc_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
F	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
F	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
E	3.90.180.10	Alpha Beta	Alpha-Beta Complex	Quinone Oxidoreductase	Chain A, domain 1	CATH (4.3.0)
E	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, F	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase	-	Domain
A, C, F	PF08240	Alcohol dehydrogenase GroES-like domain (ADH_N)	Alcohol dehydrogenase GroES-like domain	This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].	Domain
B, D, E	PF00107	Zinc-binding dehydrogenase (ADH_zinc_N)	Zinc-binding dehydrogenase	-	Domain
B, D, E	PF08240	Alcohol dehydrogenase GroES-like domain (ADH_N)	Alcohol dehydrogenase GroES-like domain	This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, F	2,4-dienoyl-CoA reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor trans-2-enoyl-CoA reductase (NADPH) activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) enoyl-[acyl-carrier-protein] reductase (NADPH) activity	fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process lipid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process lipid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle
B, D, E	2,4-dienoyl-CoA reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor trans-2-enoyl-CoA reductase (NADPH) activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity enoyl-[acyl-carrier-protein] reductase activity (NAD(P)H) enoyl-[acyl-carrier-protein] reductase (NADPH) activity	fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process lipid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process metabolic process cellular process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process lipid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process lipid biosynthetic process organic acid biosynthetic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, F	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
A, C, F	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, C, F	IPR011032	GroES-like superfamily	Homologous Superfamily
A, C, F	IPR051034	Mitochondrial Enoyl-ACP Reductase	Family
A, C, F	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain
A, C, F	IPR020843	Polyketide synthase, enoylreductase domain	Domain
B, D, E	IPR013154	Alcohol dehydrogenase-like, N-terminal	Domain
B, D, E	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
B, D, E	IPR011032	GroES-like superfamily	Homologous Superfamily
B, D, E	IPR051034	Mitochondrial Enoyl-ACP Reductase	Family
B, D, E	IPR013149	Alcohol dehydrogenase-like, C-terminal	Domain
B, D, E	IPR020843	Polyketide synthase, enoylreductase domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.