1GKG

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gkga1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	Complement receptor 1, cr1	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sushi/CCP/SCR domain	8039049	3000902	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sushi	e1gkgA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
A	Sushi_3	e1gkgA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	COMPLEMENT RECEPTOR TYPE 1	protein binding binding virus receptor activity exogenous protein binding opsonin receptor activity molecular transducer activity complement component C4b receptor activity complement receptor activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity opsonin binding complement component C4b binding complement binding protein binding binding virus receptor activity exogenous protein binding opsonin receptor activity molecular transducer activity complement component C4b receptor activity complement receptor activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity opsonin binding complement component C4b binding complement binding complement component C3b receptor activity complement component C3b binding	regulation of humoral immune response regulation of immune effector process response to stimulus negative regulation of biological process complement activation, alternative pathway response to biotic stimulus complement activation positive regulation of immune response regulation of immune system process positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism regulation of humoral immune response regulation of immune effector process response to stimulus negative regulation of biological process complement activation, alternative pathway response to biotic stimulus complement activation positive regulation of immune response regulation of immune system process positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism negative regulation of immune response regulation of innate immune response negative regulation of immune effector process negative regulation of humoral immune response response to external stimulus immune effector process regulation of response to stimulus defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of complement activation, alternative pathway regulation of complement activation activation of immune response regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus positive regulation of biological process negative regulation of complement activation positive regulation of response to stimulus response to stress regulation of response to stress innate immune response response to external biotic stimulus negative regulation of response to stimulus defense response biological regulation defense response to symbiont negative regulation of immune system process immune system process negative regulation of innate immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity leukocyte mediated immunity adaptive immune response humoral immune response mediated by circulating immunoglobulin complement activation, classical pathway immunoglobulin mediated immune response B cell mediated immunity multicellular organismal process regulation of cellular process negative regulation of interleukin-2 production regulation of cytokine production cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-2 production negative regulation of metabolic process interleukin-2 production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process membrane organization cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization immunoglobulin production negative regulation of immunoglobulin production production of molecular mediator of immune response negative regulation of production of molecular mediator of immune response regulation of immunoglobulin production regulation of production of molecular mediator of immune response cellular response to stimulus immune response-regulating cell surface receptor signaling pathway complement receptor mediated signaling pathway signaling cell communication immune response-activating signaling pathway immune response-regulating signaling pathway signal transduction cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell activation T cell activation cell differentiation anatomical structure development positive regulation of leukocyte activation T cell differentiation developmental process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process leukocyte differentiation cellular developmental process regulation of developmental process cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of cell-cell adhesion positive regulation of cellular process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation cell activation regulation of T cell activation regulatory T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of lymphocyte mediated immunity negative regulation of complement activation, classical pathway negative regulation of B cell mediated immunity regulation of adaptive immune response negative regulation of adaptive immune response regulation of B cell mediated immunity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity negative regulation of immunoglobulin mediated immune response regulation of complement activation, classical pathway regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated immunity negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion negative regulation of leukocyte activation negative regulation of lymphocyte activation leukocyte proliferation negative regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation negative regulation of cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation negative regulation of hydrolase activity negative regulation of proteolysis regulation of serine-type endopeptidase activity regulation of catalytic activity negative regulation of catalytic activity negative regulation of endopeptidase activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis regulation of serine-type peptidase activity proteolysis regulation of endopeptidase activity protein metabolic process negative regulation of protein metabolic process negative regulation of serine-type endopeptidase activity negative regulation of serine-type peptidase activity regulation of protein metabolic process regulation of peptidase activity negative regulation of molecular function primary metabolic process regulation of molecular function regulation of hydrolase activity positive regulation of cell population proliferation positive regulation of humoral immune response positive regulation of complement activation positive regulation of immune effector process activation of membrane attack complex positive regulation of activation of membrane attack complex regulation of activation of membrane attack complex regulation of complement-dependent cytotoxicity negative regulation of complement-dependent cytotoxicity regulation of cell killing complement-dependent cytotoxicity negative regulation of cell killing cell killing regulation of type II interferon production type II interferon production negative regulation of type II interferon production positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of molecular function positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of serine-type peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of serine-type endopeptidase activity positive regulation of proteolysis mature B cell differentiation B cell activation involved in immune response cell activation involved in immune response regulation of plasma cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of lymphocyte differentiation plasma cell differentiation negative regulation of plasma cell differentiation regulation of B cell differentiation B cell differentiation leukocyte activation involved in immune response regulation of B cell activation negative regulation of cell differentiation negative regulation of B cell activation lymphocyte activation involved in immune response negative regulation of B cell differentiation mature B cell differentiation involved in immune response negative regulation of developmental process B cell activation negative regulation of cell development negative regulation of activation of membrane attack complex immune complex clearance by erythrocytes immune complex clearance ATP transport nitrogen compound transport organic anion transport nucleotide transport transport purine ribonucleotide transport carbohydrate derivative transport establishment of localization purine nucleotide transport adenine nucleotide transport localization ATP export nucleobase-containing compound transport organophosphate ester transport	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface cell periphery plasma membrane membrane extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface cell periphery plasma membrane membrane intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane secretory granule membrane cytoskeleton membraneless organelle intracellular membraneless organelle ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule membrane microdomain membrane raft plasma membrane raft plasma membrane region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A	IPR050350	Complement & Cell Adhesion Regulators	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P17927	Alzheimer disease malaria Plasmodium falciparum malaria tuberculosis Acute Confusional Senile Dementia lymphoplasmacytic lymphoma nasopharyngeal carcinoma Sjogren syndrome ulcerative colitis interstitial cystitis osteosarcoma spondyloarthropathy B-cell chronic lymphocytic leukemia lung carcinoma MALT lymphoma Alzheimer disease malaria Plasmodium falciparum malaria tuberculosis Acute Confusional Senile Dementia lymphoplasmacytic lymphoma nasopharyngeal carcinoma Sjogren syndrome ulcerative colitis interstitial cystitis osteosarcoma spondyloarthropathy B-cell chronic lymphocytic leukemia lung carcinoma MALT lymphoma ovarian cancer rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.