1B57
CLASS II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE IN COMPLEX WITH PHOSPHOGLYCOLOHYDROXAMATE
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d1b57b_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Aldolase | Class II FBP aldolase | Fructose-bisphosphate aldolase (FBP aldolase) | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
A | d1b57a_ | Alpha and beta proteins (a/b) | TIM beta/alpha-barrel | Aldolase | Class II FBP aldolase | Fructose-bisphosphate aldolase (FBP aldolase) | (Escherichia coli ) [TaxId: 562 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | F_bP_aldolase | e1b57B1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: F_bP_aldolase | ECOD (1.6) |
A | F_bP_aldolase | e1b57A1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: F_bP_aldolase | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
A | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01116 | Fructose-bisphosphate aldolase class-II (F_bP_aldolase) | Fructose-bisphosphate aldolase class-II | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily | |
IPR000771 | Fructose-bisphosphate aldolase, class-II | Family | |
IPR006411 | Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype | Family |
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
fructose-bisphosphate aldolase (Class II) M-CSA #52 | Fructose-1,6-bisphosphate aldolase (FBP-aldolase, EC 4.1.2.13) participates in two major metabolic pathways. In gluconeogenesis, they catalyse the aldol condensation of a ketose, dihydroxyacetone phosphate (DHAP) and an aldose, glyceraldehyde 3-phosphate (G3P) to form the acylic form of fructose 1,6-bisphosphate (FBP). In glycolysis, they catalyse the reverse cleavage reaction. In each pathway, the enzyme-catalysed reaction represents a distinctive stage, a switch between six and three carbon units. The aldol condensation is a key reaction in synthetic chemistry that aldolases catalyse with exquisite control of the stereochemistry. | Defined by 6 residues: ASP:A-109HIS:A-110GLU:A-182HIS:A-226HIS:A-264ASN:A-286 | EC: 4.1.2.13 (PDB Primary Data) |