Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyAldolase 8043561 3000445 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyAldolase 8043561 3000445 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BF_bP_aldolasee1b57B1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: F_bP_aldolaseECOD (1.6)
AF_bP_aldolasee1b57A1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: F_bP_aldolaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01116Fructose-bisphosphate aldolase class-II (F_bP_aldolase)Fructose-bisphosphate aldolase class-II- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
PROTEIN (FRUCTOSE-BISPHOSPHATE ALDOLASE II)

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
fructose-bisphosphate aldolase (Class II)  M-CSA #52

Fructose-1,6-bisphosphate aldolase (FBP-aldolase, EC 4.1.2.13) participates in two major metabolic pathways. In gluconeogenesis, they catalyse the aldol condensation of a ketose, dihydroxyacetone phosphate (DHAP) and an aldose, glyceraldehyde 3-phosphate (G3P) to form the acylic form of fructose 1,6-bisphosphate (FBP). In glycolysis, they catalyse the reverse cleavage reaction. In each pathway, the enzyme-catalysed reaction represents a distinctive stage, a switch between six and three carbon units. The aldol condensation is a key reaction in synthetic chemistry that aldolases catalyse with exquisite control of the stereochemistry.

Aldolases have been divided into two groups, class I and class II, depending primarily on the reaction mechanism. This annotation refers to class II aldolases, which are alpha/beta(8) barrel structures. The class II enzymes are not found in mammals, and have an absolute requirement for a divalent cation, usually Zn(II), and are activated by monovalent cations.

Defined by 6 residues: ASP:A-109HIS:A-110GLU:A-182HIS:A-226HIS:A-264ASN:A-286
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